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8RHT

Crystal Structure of Trypanosoma brucei DHFR in complex with the cofactor and inhibitor P25

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0004146molecular_functiondihydrofolate reductase activity
A0046654biological_processtetrahydrofolate biosynthetic process
A0050661molecular_functionNADP binding
Functional Information from PROSITE/UniProt
site_idPS00075
Number of Residues23
DetailsDHFR_1 Dihydrofolate reductase (DHFR) domain signature. GIGdggtIPWeipe.DmqyFrrvT
ChainResidueDetails
AGLY40-THR62

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues210
DetailsDomain: {"description":"DHFR"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues24
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

248942

PDB entries from 2026-02-11

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