8RAU
The crystal structure of DNA-bound human MutSbeta (MSH2/MSH3) in the canonical mismatch bound conformation with ADP bound in MSH2 and MSH3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA mismatch repair protein Msh2 | polymer | 934 | 104861.9 | 1 | UniProt (P43246) Pfam (PF01624) Pfam (PF05188) Pfam (PF05192) Pfam (PF05190) Pfam (PF00488) | Homo sapiens (human) | hMSH2,MutS protein homolog 2 |
| 2 | B (B) | DNA mismatch repair protein Msh3 | polymer | 918 | 104289.7 | 1 | UniProt (P20585) Pfam (PF01624) Pfam (PF05188) Pfam (PF05192) Pfam (PF00488) | Homo sapiens (human) | |
| 3 | C (C) | DNA (5'-D(*TP*CP*TP*AP*TP*CP*TP*GP*AP*AP*GP*CP*CP*GP*AP*TP*CP*GP*AP*TP*GP*G)-3') | polymer | 24 | 7345.7 | 1 | synthetic construct | ||
| 4 | D (D) | DNA (5'-D(*TP*CP*AP*TP*CP*GP*AP*TP*CP*GP*CP*AP*GP*CP*TP*TP*CP*AP*GP*AP*TP*AP*GP*G)-3') | polymer | 24 | 7369.8 | 1 | synthetic construct | ||
| 5 | E, L (A, B) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 2 | Chemie (ADP) | |||
| 6 | F, M (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 7 | G, H, I, J, K... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 9 | Chemie (EDO) | |||
| 8 | R, S, T, U (A, B, C, D) | water | water | 18.0 | 374 | Chemie (HOH) |
Sequence modifications
B: 219 - 1134 (UniProt: P20585)
| PDB | External Database | Details |
|---|---|---|
| Gly 217 | - | expression tag |
| Pro 218 | - | expression tag |
| Arg 949 | Gln 949 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 223867.0 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 1461.6 | |
| All* | Total formula weight | 225328.7 |
