8R9S
A soakable crystal form of human CDK7 in complex with AMP-PNP
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Cyclin-dependent kinase 7 | polymer | 371 | 42235.6 | 2 | UniProt (P50613) Pfam (PF00069) In PDB | Homo sapiens (human) | |
2 | A, B | 3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL | non-polymer | 634.8 | 4 | Chemie (PE3) | |||
3 | A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
4 | A, B | [(3S)-1-[4-(dimethylamino)butanoyl]pyrrolidin-3-yl] 4-[(5-methyl-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-7-yl)amino]piperidine-1-carboxylate | non-polymer | 499.6 | 2 | Chemie (YPK) | |||
5 | water | water | 18.0 | 70 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 346 (UniProt: P50613)
PDB | External Database | Details |
---|---|---|
Met -24 | - | initiating methionine |
Ser -23 | - | expression tag |
Tyr -22 | - | expression tag |
Tyr -21 | - | expression tag |
His -20 | - | expression tag |
His -19 | - | expression tag |
His -18 | - | expression tag |
His -17 | - | expression tag |
His -16 | - | expression tag |
His -15 | - | expression tag |
Asp -14 | - | expression tag |
Tyr -13 | - | expression tag |
Asp -12 | - | expression tag |
Ile -11 | - | expression tag |
Pro -10 | - | expression tag |
Thr -9 | - | expression tag |
Thr -8 | - | expression tag |
Glu -7 | - | expression tag |
Asn -6 | - | expression tag |
Leu -5 | - | expression tag |
Tyr -4 | - | expression tag |
Phe -3 | - | expression tag |
Gln -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Arg 132 | Trp 132 | engineered mutation |
Asp 164 | Ser 164 | engineered mutation |
Glu 170 | Thr 170 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 84471.3 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 3644.4 | |
All* | Total formula weight | 88115.7 |