8R8E
DYRK1a in Complex with 2-Cyclopentyl-7-iodo-1H-indole-3-carbonitrile
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | polymer | 361 | 42081.5 | 3 | UniProt (Q13627) Pfam (PF00069) In PDB | Homo sapiens (human) | Dual specificity YAK1-related kinase,HP86,Protein kinase minibrain homolog,hMNB |
2 | D | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | polymer | 361 | 42001.6 | 1 | UniProt (Q13627) Pfam (PF00069) In PDB | Homo sapiens (human) | |
3 | D, A, C, B | 2-cyclopentyl-7-iodanyl-1~{H}-indole-3-carbonitrile | non-polymer | 336.2 | 4 | Chemie (YOX) | |||
4 | D, A, C, B | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 5 | Chemie (1PE) | |||
5 | A | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
6 | B, A, C | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 4 | Chemie (EPE) | |||
7 | B, A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 3 | Chemie (PEG) | |||
8 | B, D, A, C | GLYCEROL | non-polymer | 92.1 | 11 | Chemie (GOL) | |||
9 | B, A, C | 1,2-ETHANEDIOL | non-polymer | 62.1 | 6 | Chemie (EDO) | |||
10 | D, B, A, C | SULFATE ION | non-polymer | 96.1 | 25 | Chemie (SO4) | |||
11 | D | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
12 | water | water | 18.0 | 518 | Chemie (HOH) |
Sequence modifications
A, B, C: 127 - 485 (UniProt: Q13627)
D: 127 - 485 (UniProt: Q13627)
PDB | External Database | Details |
---|---|---|
Ser 125 | - | expression tag |
Met 126 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Ser 125 | - | expression tag |
Met 126 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 168246.2 | |
Non-Polymers* | Number of molecules | 60 |
Total formula weight | 7883.9 | |
All* | Total formula weight | 176130.0 |