8R8E
DYRK1a in Complex with 2-Cyclopentyl-7-iodo-1H-indole-3-carbonitrile
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGKGSFGQVVkAydrveqew..........VAIK |
| Chain | Residue | Details |
| A | ILE165-LYS188 | |
| D | ILE165-LYS188 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHcDLKpeNILL |
| Chain | Residue | Details |
| A | ILE283-LEU295 | |
| D | ILE283-LEU295 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000305|PubMed:23665168 |
| Chain | Residue | Details |
| D | CYS296 | |
| B | ASP287 | |
| C | ASP287 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000305 |
| Chain | Residue | Details |
| D | VAL174 | |
| D | LEU197 | |
| D | ASP247 | |
| B | ILE165 | |
| B | LYS188 | |
| B | PHE238 | |
| C | ILE165 | |
| C | LYS188 | |
| C | PHE238 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:23665168 |
| Chain | Residue | Details |
| D | VAL149 | |
| B | TYR319 | |
| B | PTR321 | |
| B | TYR449 | |
| C | TYR140 | |
| C | TYR159 | |
| C | TYR177 | |
| C | TYR319 | |
| C | PTR321 | |
| C | TYR449 | |
| D | GLY168 | |
| D | ALA186 | |
| D | ARG328 | |
| D | PRO330 | |
| D | ARG458 | |
| B | TYR140 | |
| B | TYR159 | |
| B | TYR177 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| D | LYS154 | |
| B | TYR145 | |
| C | TYR145 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000250|UniProtKB:Q63470 |
| Chain | Residue | Details |
| D | PHE228 | |
| B | TYR219 | |
| C | TYR219 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|PubMed:23665168 |
| Chain | Residue | Details |
| D | TYR319 | |
| B | SER310 | |
| C | SER310 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:23665168 |
| Chain | Residue | Details |
| D | GLY411 | |
| B | THR402 | |
| C | THR402 |
