8R7V
MutSbeta bound to compound CHDI-00898647 in the canonical DNA-mismatch bound form
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA mismatch repair protein Msh2 | polymer | 934 | 104861.9 | 1 | UniProt (P43246) Pfam (PF01624) Pfam (PF05188) Pfam (PF05192) Pfam (PF05190) Pfam (PF00488) | Homo sapiens (human) | hMSH2,MutS protein homolog 2 |
| 2 | B (B) | DNA mismatch repair protein Msh3 | polymer | 1137 | 127634.7 | 1 | UniProt (P20585) Pfam (PF01624) Pfam (PF05188) Pfam (PF05192) Pfam (PF00488) | Homo sapiens (human) | hMSH3,Divergent upstream protein,DUP,Mismatch repair protein 1,MRP1 |
| 3 | C (C) | DNA_61bp_Complement_Rev | polymer | 60 | 18491.8 | 1 | Homo sapiens | ||
| 4 | D (D) | DNA_61bp_CAG2_loop_Fwd | polymer | 66 | 20355.0 | 1 | Homo sapiens | ||
| 5 | E (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 6 | F (A) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 7 | G (B) | ~{N}-[3-[[2-[[3-fluoranyl-4-(4-methylpiperazin-1-yl)phenyl]amino]-7~{H}-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenyl]prop-2-enamide | non-polymer | 487.5 | 1 | Chemie (YKQ) | |||
| 8 | H (B) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) |
Sequence modifications
B: 1 - 1137 (UniProt: P20585)
| PDB | External Database | Details |
|---|---|---|
| Val 79 | Ile 79 | variant |
| Arg 949 | Gln 949 | variant |
| Thr 1045 | Ala 1045 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 271343.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1035.1 | |
| All* | Total formula weight | 272378.6 |
