8R5Q
Structure of apo TDO with a bound inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Tryptophan 2,3-dioxygenase | polymer | 358 | 42878.0 | 4 | UniProt (P48775) Pfam (PF03301) | Homo sapiens (human) | |
| 2 | E, G, I, K (A, B, C, D) | 3-chloranyl-~{N}-[(1~{S})-1-(6-chloranylpyridin-3-yl)-2-phenyl-ethyl]aniline | non-polymer | 343.3 | 4 | Chemie (Y5N) | |||
| 3 | F, H, J, L (A, B, C, D) | alpha-methyl-L-tryptophan | non-polymer | 218.3 | 4 | Chemie (ZIQ) | |||
| 4 | M, N (A, B) | water | water | 18.0 | 5 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 39 - 389 (UniProt: P48775)
| PDB | External Database | Details |
|---|---|---|
| Glu 390 | - | expression tag |
| His 391 | - | expression tag |
| His 392 | - | expression tag |
| His 393 | - | expression tag |
| His 394 | - | expression tag |
| His 395 | - | expression tag |
| His 396 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 171512.1 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2246.0 | |
| All* | Total formula weight | 173758.1 |
