8R5Q

Structure of apo TDO with a bound inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004833	molecular_function	tryptophan 2,3-dioxygenase activity
A	0019441	biological_process	tryptophan catabolic process to kynurenine
A	0020037	molecular_function	heme binding
A	0046872	molecular_function	metal ion binding
B	0004833	molecular_function	tryptophan 2,3-dioxygenase activity
B	0019441	biological_process	tryptophan catabolic process to kynurenine
B	0020037	molecular_function	heme binding
B	0046872	molecular_function	metal ion binding
C	0004833	molecular_function	tryptophan 2,3-dioxygenase activity
C	0019441	biological_process	tryptophan catabolic process to kynurenine
C	0020037	molecular_function	heme binding
C	0046872	molecular_function	metal ion binding
D	0004833	molecular_function	tryptophan 2,3-dioxygenase activity
D	0019441	biological_process	tryptophan catabolic process to kynurenine
D	0020037	molecular_function	heme binding
D	0046872	molecular_function	metal ion binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03020, ECO:0000269|PubMed:27762317, ECO:0007744|PDB:5TI9

Chain	Residue	Details
A	PHE72
D	PHE72
D	ARG144
D	THR342
A	ARG144
A	THR342
B	PHE72
B	ARG144
B	THR342
C	PHE72
C	ARG144
C	THR342

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: axial binding residue => ECO:0000255|HAMAP-Rule:MF_03020, ECO:0000269|PubMed:27762317, ECO:0007744|PDB:5TI9

Chain	Residue	Details
A	HIS328
B	HIS328
C	HIS328
D	HIS328

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