8R3U
Crystal structure of DHPS in complex with an inhibitor
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (AAA, BBB, CCC, DDD) | Deoxyhypusine synthase | polymer | 370 | 41025.4 | 4 | UniProt (P49366) Pfam (PF01916) | Homo sapiens (human) | |
| 2 | E, K, P, X (AAA, BBB, CCC, DDD) | 2-[(2~{R})-1-azanyl-4-methyl-pentan-2-yl]-5-pyridin-3-yl-isoquinolin-1-one | non-polymer | 321.4 | 4 | Chemie (XTQ) | |||
| 3 | AA, F, G, H, I... (DDD, AAA, BBB, CCC) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 18 | Chemie (EDO) | |||
| 4 | BA, V (DDD, CCC) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 2 | Chemie (DMS) | |||
| 5 | CA, DA, EA, FA (AAA, BBB, CCC, DDD) | water | water | 18.0 | 940 | Chemie (HOH) |
Sequence modifications
AAA, BBB, CCC, DDD: 2 - 369 (UniProt: P49366)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Ser 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 164101.5 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 2559.2 | |
| All* | Total formula weight | 166660.6 |
