8R3U

Crystal structure of DHPS in complex with an inhibitor

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0005515	molecular_function	protein binding
AAA	0005737	cellular_component	cytoplasm
AAA	0005829	cellular_component	cytosol
AAA	0006412	biological_process	translation
AAA	0008216	biological_process	spermidine metabolic process
AAA	0008284	biological_process	positive regulation of cell population proliferation
AAA	0008612	biological_process	peptidyl-lysine modification to peptidyl-hypusine
AAA	0016740	molecular_function	transferase activity
AAA	0034038	molecular_function	deoxyhypusine synthase activity
AAA	0042102	biological_process	positive regulation of T cell proliferation
AAA	0042593	biological_process	glucose homeostasis
AAA	0042802	molecular_function	identical protein binding
AAA	0046203	biological_process	spermidine catabolic process
AAA	0051604	biological_process	protein maturation
BBB	0005515	molecular_function	protein binding
BBB	0005737	cellular_component	cytoplasm
BBB	0005829	cellular_component	cytosol
BBB	0006412	biological_process	translation
BBB	0008216	biological_process	spermidine metabolic process
BBB	0008284	biological_process	positive regulation of cell population proliferation
BBB	0008612	biological_process	peptidyl-lysine modification to peptidyl-hypusine
BBB	0016740	molecular_function	transferase activity
BBB	0034038	molecular_function	deoxyhypusine synthase activity
BBB	0042102	biological_process	positive regulation of T cell proliferation
BBB	0042593	biological_process	glucose homeostasis
BBB	0042802	molecular_function	identical protein binding
BBB	0046203	biological_process	spermidine catabolic process
BBB	0051604	biological_process	protein maturation
CCC	0005515	molecular_function	protein binding
CCC	0005737	cellular_component	cytoplasm
CCC	0005829	cellular_component	cytosol
CCC	0006412	biological_process	translation
CCC	0008216	biological_process	spermidine metabolic process
CCC	0008284	biological_process	positive regulation of cell population proliferation
CCC	0008612	biological_process	peptidyl-lysine modification to peptidyl-hypusine
CCC	0016740	molecular_function	transferase activity
CCC	0034038	molecular_function	deoxyhypusine synthase activity
CCC	0042102	biological_process	positive regulation of T cell proliferation
CCC	0042593	biological_process	glucose homeostasis
CCC	0042802	molecular_function	identical protein binding
CCC	0046203	biological_process	spermidine catabolic process
CCC	0051604	biological_process	protein maturation
DDD	0005515	molecular_function	protein binding
DDD	0005737	cellular_component	cytoplasm
DDD	0005829	cellular_component	cytosol
DDD	0006412	biological_process	translation
DDD	0008216	biological_process	spermidine metabolic process
DDD	0008284	biological_process	positive regulation of cell population proliferation
DDD	0008612	biological_process	peptidyl-lysine modification to peptidyl-hypusine
DDD	0016740	molecular_function	transferase activity
DDD	0034038	molecular_function	deoxyhypusine synthase activity
DDD	0042102	biological_process	positive regulation of T cell proliferation
DDD	0042593	biological_process	glucose homeostasis
DDD	0042802	molecular_function	identical protein binding
DDD	0046203	biological_process	spermidine catabolic process
DDD	0051604	biological_process	protein maturation

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	44
Details	Binding site: {"evidences":[{"source":"PubMed","id":"9493264","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17525332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"9405486","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA2
Number of Residues	3
Details	M-CSA 687

Chain

Residue

Details

---

site_id	MCSA3
Number of Residues	3
Details	M-CSA 687

Chain

Residue

Details

---

site_id	MCSA1
Number of Residues	2
Details	M-CSA 687

Chain

Residue

Details

---

site_id	MCSA4
Number of Residues	2
Details	M-CSA 687

Chain

Residue

Details

---