8R1J

Structure of avian H5N1 influenza A polymerase dimer in complex with human ANP32B.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D	Polymerase acidic protein	polymer	716	82600.3	2	UniProt (A5Z236) Pfam (PF00603) In PDB	Influenza A virus
2	B, E	RNA-directed RNA polymerase catalytic subunit	polymer	757	86616.3	2	UniProt (A5Z231) Pfam (PF00602) In PDB	Influenza A virus
3	C, F	Polymerase basic protein 2	polymer	898	101380.0	2		Influenza A virus
4	G	Acidic leucine-rich nuclear phosphoprotein 32 family member B	polymer	251	28816.7	1	UniProt (Q92688) Pfam (PF12799) In PDB	Homo sapiens (human)

Sequence modifications

A, D: 4 - 716 (UniProt: A5Z236)

PDB	External Database	Details
Met 1	-	variant
Glu 2	-	variant
Asp 3	-	variant
Arg 556	Gln 553	engineered mutation

B, E: 4 - 757 (UniProt: A5Z231)

PDB	External Database	Details
Met 1	-	variant
Asp 2	-	variant
Val 3	-	variant
Glu 577	Lys 574	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	7
	Total formula weight	570009.9
All*	Total formula weight	570009.9

*Water molecules are not included.