8R1J

Structure of avian H5N1 influenza A polymerase dimer in complex with human ANP32B.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0004518	molecular_function	nuclease activity
A	0004519	molecular_function	endonuclease activity
A	0016787	molecular_function	hydrolase activity
A	0030430	cellular_component	host cell cytoplasm
A	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
A	0039657	biological_process	symbiont-mediated suppression of host gene expression
A	0039694	biological_process	viral RNA genome replication
A	0042025	cellular_component	host cell nucleus
A	0046872	molecular_function	metal ion binding
A	0075523	biological_process	viral translational frameshifting
A	0075526	biological_process	cap snatching
B	0000166	molecular_function	nucleotide binding
B	0001172	biological_process	RNA-templated transcription
B	0003723	molecular_function	RNA binding
B	0003968	molecular_function	RNA-directed RNA polymerase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0019083	biological_process	viral transcription
B	0030430	cellular_component	host cell cytoplasm
B	0034062	molecular_function	5'-3' RNA polymerase activity
B	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
B	0039657	biological_process	symbiont-mediated suppression of host gene expression
B	0039694	biological_process	viral RNA genome replication
B	0042025	cellular_component	host cell nucleus
C	0003723	molecular_function	RNA binding
C	0006351	biological_process	DNA-templated transcription
C	0006370	biological_process	7-methylguanosine mRNA capping
C	0006397	biological_process	mRNA processing
C	0019083	biological_process	viral transcription
C	0019865	molecular_function	immunoglobulin binding
C	0033650	cellular_component	host cell mitochondrion
C	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
C	0039657	biological_process	symbiont-mediated suppression of host gene expression
C	0039694	biological_process	viral RNA genome replication
C	0042025	cellular_component	host cell nucleus
C	0044423	cellular_component	virion component
C	0075526	biological_process	cap snatching
D	0003723	molecular_function	RNA binding
D	0004518	molecular_function	nuclease activity
D	0004519	molecular_function	endonuclease activity
D	0016787	molecular_function	hydrolase activity
D	0030430	cellular_component	host cell cytoplasm
D	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
D	0039657	biological_process	symbiont-mediated suppression of host gene expression
D	0039694	biological_process	viral RNA genome replication
D	0042025	cellular_component	host cell nucleus
D	0046872	molecular_function	metal ion binding
D	0075523	biological_process	viral translational frameshifting
D	0075526	biological_process	cap snatching
E	0000166	molecular_function	nucleotide binding
E	0001172	biological_process	RNA-templated transcription
E	0003723	molecular_function	RNA binding
E	0003968	molecular_function	RNA-directed RNA polymerase activity
E	0016779	molecular_function	nucleotidyltransferase activity
E	0019083	biological_process	viral transcription
E	0030430	cellular_component	host cell cytoplasm
E	0034062	molecular_function	5'-3' RNA polymerase activity
E	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
E	0039657	biological_process	symbiont-mediated suppression of host gene expression
E	0039694	biological_process	viral RNA genome replication
E	0042025	cellular_component	host cell nucleus
F	0003723	molecular_function	RNA binding
F	0006351	biological_process	DNA-templated transcription
F	0006370	biological_process	7-methylguanosine mRNA capping
F	0006397	biological_process	mRNA processing
F	0019083	biological_process	viral transcription
F	0019865	molecular_function	immunoglobulin binding
F	0033650	cellular_component	host cell mitochondrion
F	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
F	0039657	biological_process	symbiont-mediated suppression of host gene expression
F	0039694	biological_process	viral RNA genome replication
F	0042025	cellular_component	host cell nucleus
F	0044423	cellular_component	virion component
F	0075526	biological_process	cap snatching
G	0001944	biological_process	vasculature development
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005730	cellular_component	nucleolus
G	0005737	cellular_component	cytoplasm
G	0006334	biological_process	nucleosome assembly
G	0021591	biological_process	ventricular system development
G	0042393	molecular_function	histone binding
G	0042981	biological_process	regulation of apoptotic process
G	0043066	biological_process	negative regulation of apoptotic process
G	0045596	biological_process	negative regulation of cell differentiation
G	0046827	biological_process	positive regulation of protein export from nucleus
G	0048839	biological_process	inner ear development
G	0060021	biological_process	roof of mouth development
G	0070062	cellular_component	extracellular exosome
G	0070063	molecular_function	RNA polymerase binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
G	LYS86

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9EST6

Chain	Residue	Details
G	SER158

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:17178712, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18318008, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
G	THR244

---