8QY9
J22.9-H, fully humanized Fab Fragment based on chimeric J22.9-xi IgG against BCMA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L) | Fab light chain of J22.9-H | polymer | 211 | 23034.6 | 1 | Mus musculus | ||
| 2 | B (H) | Fab heavy chain of J22.9-H | polymer | 221 | 23572.3 | 1 | Mus musculus | ||
| 3 | C (A) | Tumor necrosis factor receptor superfamily member 17 | polymer | 35 | 3741.3 | 1 | UniProt (Q02223) Pfam (PF09257) | Homo sapiens (human) | B-cell maturation protein |
| 4 | D, E (L, H) | COPPER (II) ION | non-polymer | 63.5 | 2 | Chemie (CU) |
Sequence modifications
A: 7 - 41 (UniProt: Q02223)
| PDB | External Database | Details |
|---|---|---|
| Ala 10 | Gln 10 | engineered mutation |
| Ala 31 | Asn 31 | engineered mutation |
| Ala 35 | Leu 35 | engineered mutation |
| Ala 38 | Gln 38 | engineered mutation |
| Ala 39 | Arg 39 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 50348.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 127.1 | |
| All* | Total formula weight | 50475.3 |
