8QT4
Crystal structure of human Sirt2 in complex with the super-slow substrate TNFn-6 and NAD+
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | NAD-dependent protein deacetylase sirtuin-2 | polymer | 304 | 34416.7 | 1 | UniProt (Q8IXJ6) Pfam (PF02146) | Homo sapiens (human) | Regulatory protein SIR2 homolog 2,SIR2-like protein 2 |
| 2 | B (B) | Peptide-based super-slow substrate TNFn-6 | polymer | 10 | 1007.1 | 1 | Homo sapiens | ||
| 3 | C (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D, E, I, L (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 5 | F (A) | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 209.2 | 1 | Chemie (BTB) | |||
| 6 | G (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 7 | H (A) | (R,R)-2,3-BUTANEDIOL | non-polymer | 90.1 | 1 | Chemie (BU3) | |||
| 8 | J (A) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 9 | K (A) | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 1 | Chemie (NAD) | |||
| 10 | M (B) | 3-dodecylsulfanyl-2,2-dimethyl-propanoic acid | non-polymer | 302.5 | 1 | Chemie (WU8) | |||
| 11 | N, O (A, B) | water | water | 18.0 | 278 | Chemie (HOH) |
Sequence modifications
A: 56 - 356 (UniProt: Q8IXJ6)
| PDB | External Database | Details |
|---|---|---|
| Gly 53 | - | expression tag |
| His 54 | - | expression tag |
| Met 55 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35423.8 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1807.3 | |
| All* | Total formula weight | 37231.1 |
