8QQG
Structure of BRAF in Complex With Exarafenib (KIN-2787).
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C | Serine/threonine-protein kinase B-raf | polymer | 275 | 31351.3 | 3 | UniProt (P15056) Pfam (PF07714) In PDB | Homo sapiens (human) | Proto-oncogene B-Raf,p94,v-Raf murine sarcoma viral oncogene homolog B1 |
| 2 | A, B, C | (3~{S})-~{N}-[4-methyl-3-[2-morpholin-4-yl-6-[[(2~{R})-1-oxidanylpropan-2-yl]amino]pyridin-4-yl]phenyl]-3-[2,2,2-tris(fluoranyl)ethyl]pyrrolidine-1-carboxamide | non-polymer | 521.6 | 3 | Chemie (WJ9) | |||
| 3 | A, B, C | CHLORIDE ION | non-polymer | 35.5 | 7 | Chemie (CL) | |||
| 4 | water | water | 18.0 | 80 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 94054.0 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1812.9 | |
| All* | Total formula weight | 95866.9 |
