8QLR

Human MST3 (STK24) kinase in complex with inhibitor MR24

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B, A	Serine/threonine-protein kinase 24	polymer	306	34559.6	2	UniProt (Q9Y6E0) Pfam (PF00069) In PDB	Homo sapiens (human)	Mammalian STE20-like protein kinase 3,MST-3,STE20-like kinase MST3
2	B, A	8-(4-azanylbutyl)-2-[1,3-bis(oxidanyl)propan-2-ylamino]-6-[2-chloranyl-4-(6-methylpyridin-2-yl)phenyl]pyrido[2,3-d]pyrimidin-7-one	non-polymer		509.0	2	Chemie (VYN)
3	B, A	1,2-ETHANEDIOL	non-polymer		62.1	3	Chemie (EDO)
4		water	water		18.0	200	Chemie (HOH)

Sequence modifications

B, A: 4 - 301 (UniProt: Q9Y6E0)

PDB	External Database	Details
Met 3	-	initiating methionine
Ala 302	-	expression tag
His 303	-	expression tag
His 304	-	expression tag
His 305	-	expression tag
His 306	-	expression tag
His 307	-	expression tag
His 308	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	69119.3
Non-Polymers*	Number of molecules	5
	Total formula weight	1204.2
All*	Total formula weight	70323.5

*Water molecules are not included.