8QLR
Human MST3 (STK24) kinase in complex with inhibitor MR24
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGKGSFGEVFkGidnrtqkv..........VAIK |
| Chain | Residue | Details |
| B | ILE42-LYS65 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159 |
| Chain | Residue | Details |
| B | ASP156 | |
| A | ASP156 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | BINDING: |
| Chain | Residue | Details |
| B | ILE42 | |
| A | ASP174 | |
| B | LYS65 | |
| B | GLU112 | |
| B | ASN161 | |
| B | ASP174 | |
| A | ILE42 | |
| A | LYS65 | |
| A | GLU112 | |
| A | ASN161 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by PKA => ECO:0000269|PubMed:10644707 |
| Chain | Residue | Details |
| B | THR18 | |
| A | THR18 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:17046825, ECO:0000269|PubMed:19604147, ECO:0000269|PubMed:20124694, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | THR190 | |
| A | THR190 |
