8QJT
BRM (SMARCA2) Bromodomain in complex with ligand 10
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Probable global transcription activator SNF2L2 | polymer | 123 | 14380.5 | 3 | UniProt (P51531) Pfam (PF00439) | Homo sapiens (human) | ATP-dependent helicase SMARCA2,BRG1-associated factor 190B,BAF190B,Protein brahma homolog,hBRM,SNF2-alpha,SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 |
| 2 | D, E, G, J (A, B, C) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | F, I, K (A, B, C) | 2-[6-azanyl-5-[(1R,5S)-8-[2-(2-methoxyethoxy)pyridin-4-yl]-3,8-diazabicyclo[3.2.1]octan-3-yl]pyridazin-3-yl]phenol | non-polymer | 448.5 | 3 | Chemie (VLC) | |||
| 4 | H (B) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | L, M, N (A, B, C) | water | water | 18.0 | 143 | Chemie (HOH) |
Sequence modifications
A, B, C: 1373 - 1493 (UniProt: P51531)
| PDB | External Database | Details |
|---|---|---|
| Ser 1371 | - | expression tag |
| Met 1372 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 43141.6 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1642.6 | |
| All* | Total formula weight | 44784.3 |
