8QJ7
Cryo-EM structure of human DNA polymerase alpha-primase in pre-initiation stage 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | C | DNA primase small subunit | polymer | 420 | 49981.0 | 1 | UniProt (P49642) Pfam (PF01896) In PDB | Homo sapiens (human) | |
| 2 | A | DNA polymerase alpha catalytic subunit | polymer | 1462 | 166131.1 | 1 | UniProt (P09884) Pfam (PF12254) Pfam (PF03104) Pfam (PF00136) Pfam (PF08996) In PDB | Homo sapiens (human) | |
| 3 | B | DNA polymerase alpha subunit B | polymer | 598 | 66015.5 | 1 | UniProt (Q14181) Pfam (PF08418) Pfam (PF22062) Pfam (PF04042) In PDB | Homo sapiens (human) | DNA polymerase alpha 70 kDa subunit |
| 4 | D | DNA primase large subunit | polymer | 509 | 58890.9 | 1 | UniProt (P49643) Pfam (PF04104) In PDB | Homo sapiens (human) | DNA primase 58 kDa subunit,p58 |
| 5 | C, A | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 6 | C | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
| 7 | C | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (ATP) | |||
| 8 | D | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 1 | Chemie (SF4) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 341018.6 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1164.9 | |
| All* | Total formula weight | 342183.5 |
