8QJ2
Structure of active state MC4R in complex with a potent ligand mimicking nanobody
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 394 | 45699.4 | 1 | UniProt (P63092) Pfam (PF00503) In PDB | Homo sapiens (human) | |
2 | C | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 350 | 38534.1 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | |
3 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
4 | N | Nanobody-35 | polymer | 138 | 15140.7 | 1 | Lama glama | ||
5 | A | Soluble cytochrome b562,Melanocortin receptor 4,Red fluorescent protein drFP583 | polymer | 729 | 82025.1 | 1 | UniProt (P0ABE7) UniProt (P32245) UniProt (Q9U6Y8) Pfam (PF07361) Pfam (PF00001) Pfam (PF01353) In PDB | Escherichia coli | Cytochrome b-562,MC4-R,DsRed |
6 | D | pN162 | polymer | 117 | 12655.2 | 1 | Lama glama |
Sequence modifications
B: 1 - 394 (UniProt: P63092)
C: 2 - 340 (UniProt: P62873)
A: -114 - -9 (UniProt: P0ABE7)
A: 1 - 332 (UniProt: P32245)
A: 352 - 565 (UniProt: Q9U6Y8)
PDB | External Database | Details |
---|---|---|
Asn 54 | Ser 54 | engineered mutation |
Ala 226 | Gly 226 | engineered mutation |
Ala 268 | Glu 268 | engineered mutation |
Lys 271 | Asn 271 | engineered mutation |
Asp 274 | Lys 274 | engineered mutation |
Lys 280 | Arg 280 | engineered mutation |
Asp 284 | Thr 284 | engineered mutation |
Thr 285 | Ile 285 | engineered mutation |
Ser 366 | Ala 366 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met -9 | - | initiating methionine |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
Gly 1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Phe -124 | - | expression tag |
Ala -123 | - | expression tag |
Asp -122 | - | expression tag |
Tyr -121 | - | expression tag |
Lys -120 | - | expression tag |
Asp -119 | - | expression tag |
Asp -118 | - | expression tag |
Asp -117 | - | expression tag |
Asp -116 | - | expression tag |
Lys -115 | - | expression tag |
Trp -107 | Met 29 | engineered mutation |
Ile -12 | His 124 | engineered mutation |
Leu -8 | - | linker |
Leu -7 | - | linker |
Glu -6 | - | linker |
Val -5 | - | linker |
Leu -4 | - | linker |
Phe -3 | - | linker |
Gln -2 | - | linker |
Gly -1 | - | linker |
Pro 0 | - | linker |
PDB | External Database | Details |
---|---|---|
Leu 333 | - | linker |
Glu 334 | - | linker |
Val 335 | - | linker |
Leu 336 | - | linker |
Phe 337 | - | linker |
Gln 338 | - | linker |
Gly 339 | - | linker |
Pro 340 | - | linker |
Val 341 | - | linker |
Ser 342 | - | linker |
Lys 343 | - | linker |
Gly 344 | - | linker |
Glu 345 | - | linker |
Glu 346 | - | linker |
Asp 347 | - | linker |
Asn 348 | - | linker |
Met 349 | - | linker |
Ala 350 | - | linker |
Ile 351 | - | linker |
PDB | External Database | Details |
---|---|---|
His 361 | Arg 17 | engineered mutation |
Ser 365 | Thr 21 | engineered mutation |
Thr 385 | His 41 | engineered mutation |
Gln 386 | Asn 42 | engineered mutation |
Ala 388 | Val 44 | engineered mutation |
Met 410 | Gln 66 | engineered mutation |
Ala 415 | Val 71 | engineered mutation |
Leu 427 | Lys 83 | engineered mutation |
Glu 461 | Cys 117 | engineered mutation |
Leu 468 | Phe 124 | engineered mutation |
Arg 469 | Ile 125 | engineered mutation |
Thr 471 | Val 127 | engineered mutation |
Ser 491 | Thr 147 | engineered mutation |
Met 494 | Leu 150 | engineered mutation |
Glu 497 | Arg 153 | engineered mutation |
Ala 500 | Val 156 | engineered mutation |
Lys 506 | His 162 | engineered mutation |
Gln 507 | Lys 163 | engineered mutation |
Arg 508 | Ala 164 | engineered mutation |
Asp 518 | Leu 174 | engineered mutation |
Ala 519 | Val 175 | engineered mutation |
Val 521 | Phe 177 | engineered mutation |
Thr 523 | Ser 179 | engineered mutation |
Thr 524 | Ile 180 | engineered mutation |
Lys 526 | Met 182 | engineered mutation |
Ala 536 | Tyr 192 | engineered mutation |
Asn 538 | Tyr 194 | engineered mutation |
Asn 540 | Asp 196 | engineered mutation |
Ile 541 | Ser 197 | engineered mutation |
Ala 561 | Thr 217 | engineered mutation |
Ser 566 | - | expression tag |
Thr 567 | - | expression tag |
Gly 568 | - | expression tag |
Gly 569 | - | expression tag |
Met 570 | - | expression tag |
Asp 571 | - | expression tag |
Glu 572 | - | expression tag |
Leu 573 | - | expression tag |
Tyr 574 | - | expression tag |
Lys 575 | - | expression tag |
His 576 | - | expression tag |
His 577 | - | expression tag |
His 578 | - | expression tag |
His 579 | - | expression tag |
His 580 | - | expression tag |
His 581 | - | expression tag |
His 582 | - | expression tag |
His 583 | - | expression tag |
His 584 | - | expression tag |
His 585 | - | expression tag |
Gly 586 | - | expression tag |
Leu 587 | - | expression tag |
Asn 588 | - | expression tag |
Asp 589 | - | expression tag |
Ile 590 | - | expression tag |
Phe 591 | - | expression tag |
Glu 592 | - | expression tag |
Ala 593 | - | expression tag |
Gln 594 | - | expression tag |
Lys 595 | - | expression tag |
Ile 596 | - | expression tag |
Glu 597 | - | expression tag |
Trp 598 | - | expression tag |
His 599 | - | expression tag |
Glu 600 | - | expression tag |
Glu 601 | - | expression tag |
Pro 602 | - | expression tag |
Glu 603 | - | expression tag |
Ala 604 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 201915.7 | |
All* | Total formula weight | 201915.7 |