8QJ2
Structure of active state MC4R in complex with a potent ligand mimicking nanobody
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIcSLLSIAVDRYFtI |
| Chain | Residue | Details |
| A | ALA135-ILE151 |
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS |
| Chain | Residue | Details |
| C | LEU70-SER84 | |
| C | ILE157-ILE171 | |
| C | LEU285-ALA299 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| G | ALA2 | |
| B | ASN54 | |
| B | LEU197 | |
| B | THR204 | |
| B | ASP223 | |
| B | ASN292 | |
| B | SER366 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Cysteine methyl ester => ECO:0000250|UniProtKB:P63212 |
| Chain | Residue | Details |
| G | CYS68 | |
| A | LEU107-ASN123 | |
| A | TYR187-SER191 | |
| A | PRO272-PHE280 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | LIPID: S-geranylgeranyl cysteine => ECO:0000250|UniProtKB:P63212 |
| Chain | Residue | Details |
| G | CYS68 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | LIPID: N-palmitoyl glycine => ECO:0000250|UniProtKB:P04896 |
| Chain | Residue | Details |
| B | GLY2 | |
| A | ASP146-ARG165 | |
| A | PHE216-THR248 | |
| A | ARG305-TYR332 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:21044946 |
| Chain | Residue | Details |
| B | CYS3 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) |
| Chain | Residue | Details |
| B | LYS300 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL166-ILE186 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000255 |
| Chain | Residue | Details |
| A | ALA192-MET215 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE249-CYS271 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000255 |
| Chain | Residue | Details |
| A | MET281-LEU304 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000255 |
| Chain | Residue | Details |
| A | CYS318 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN3 | |
| A | ASN17 | |
| A | ASN26 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | MOD_RES: (Z)-2,3-didehydrotyrosine => ECO:0000269|PubMed:11209050 |
| Chain | Residue | Details |
| A | TYR411 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | CROSSLNK: 2-iminomethyl-5-imidazolinone (Gln-Gly) => ECO:0000269|PubMed:11209050 |
| Chain | Residue | Details |
| A | MET410 | |
| A | GLY412 |
