8QEL

PKR kinase domain- eIF2alpha in complex with compound

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Eukaryotic translation initiation factor 2 subunit alpha	polymer	173	20409.7	1	UniProt (P20459) Pfam (PF00575) Pfam (PF07541) In PDB	Saccharomyces cerevisiae (baker's yeast)	eIF-2-alpha
2	B	Interferon-induced, double-stranded RNA-activated protein kinase	polymer	273	31589.3	1	UniProt (P19525) Pfam (PF00069) In PDB	Homo sapiens (human)	Eukaryotic translation initiation factor 2-alpha kinase 2,eIF-2A protein kinase 2,Interferon-inducible RNA-dependent protein kinase,P1/eIF-2A protein kinase,Protein kinase RNA-activated,PKR,Protein kinase R,Tyrosine-protein kinase EIF2AK2,p68 kinase
3	B	(3~{Z})-3-[(4-methyl-1~{H}-imidazol-5-yl)methylidene]-2-oxidanylidene-1~{H}-indole-5-carboxamide	non-polymer		268.3	1	Chemie (UH3)

Sequence modifications

B: 258 - 337 (UniProt: P19525)

PDB	External Database	Details
Ala 256	-	expression tag
His 257	-	expression tag

B: 357 - 541 (UniProt: P19525)

PDB	External Database	Details
Ser 351	-	linker
Lys 352	-	linker
Asn 353	-	linker
Ser 354	-	linker
Ser 355	-	linker
Arg 356	-	linker
Asn 412	His 412	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	51998.9
Non-Polymers*	Number of molecules	1
	Total formula weight	268.3
All*	Total formula weight	52267.2

*Water molecules are not included.