8QEL
PKR kinase domain- eIF2alpha in complex with compound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Eukaryotic translation initiation factor 2 subunit alpha | polymer | 173 | 20409.7 | 1 | UniProt (P20459) Pfam (PF00575) Pfam (PF07541) | Saccharomyces cerevisiae (baker's yeast) | eIF-2-alpha |
| 2 | B (B) | Interferon-induced, double-stranded RNA-activated protein kinase | polymer | 273 | 31589.3 | 1 | UniProt (P19525) Pfam (PF00069) | Homo sapiens (human) | Eukaryotic translation initiation factor 2-alpha kinase 2,eIF-2A protein kinase 2,Interferon-inducible RNA-dependent protein kinase,P1/eIF-2A protein kinase,Protein kinase RNA-activated,PKR,Protein kinase R,Tyrosine-protein kinase EIF2AK2,p68 kinase |
| 3 | C (B) | (3~{Z})-3-[(4-methyl-1~{H}-imidazol-5-yl)methylidene]-2-oxidanylidene-1~{H}-indole-5-carboxamide | non-polymer | 268.3 | 1 | Chemie (UH3) |
Sequence modifications
B: 258 - 337 (UniProt: P19525)
B: 357 - 541 (UniProt: P19525)
| PDB | External Database | Details |
|---|---|---|
| Ala 256 | - | expression tag |
| His 257 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 351 | - | linker |
| Lys 352 | - | linker |
| Asn 353 | - | linker |
| Ser 354 | - | linker |
| Ser 355 | - | linker |
| Arg 356 | - | linker |
| Asn 412 | His 412 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 51998.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 268.3 | |
| All* | Total formula weight | 52267.2 |
