8QA6
MTHFR + SAM inhibited state
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Methylenetetrahydrofolate reductase (NADPH) | polymer | 663 | 75461.2 | 2 | UniProt (P42898) Pfam (PF02219) Pfam (PF21895) In PDB | Homo sapiens (human) | |
2 | A, B | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 4 | Chemie (SAM) | |||
3 | A, B | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 2 | Chemie (FAD) |
Sequence modifications
A, B: 1 - 656 (UniProt: P42898)
PDB | External Database | Details |
---|---|---|
Ala 429 | Glu 429 | conflict |
Gln 594 | Arg 594 | conflict |
Ala 657 | - | expression tag |
Glu 658 | - | expression tag |
Asn 659 | - | expression tag |
Leu 660 | - | expression tag |
Tyr 661 | - | expression tag |
Phe 662 | - | expression tag |
Gln 663 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 150922.4 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 3164.8 | |
All* | Total formula weight | 154087.2 |