8QA6
MTHFR + SAM inhibited state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Methylenetetrahydrofolate reductase (NADPH) | polymer | 663 | 75461.2 | 2 | UniProt (P42898) Pfam (PF02219) Pfam (PF21895) | Homo sapiens (human) | |
| 2 | C, E, F, H (A, B) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 4 | Chemie (SAM) PubChem (5136) PubChem (34755) PubChem (58633578) PubChem (60038769) PubChem (73897310) PubChem (58766358) PubChem (87224684) PubChem (131697735) PubChem (9865603) PubChem (145712080) PubChem (12312798) PubChem (132988922) PubChem (134692588) PubChem (135030730) PubChem (140459785) PubChem (163046094) | |||
| 3 | D, G (A, B) | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 2 | Chemie (FAD) |
Sequence modifications
A, B: 1 - 656 (UniProt: P42898)
| PDB | External Database | Details |
|---|---|---|
| Ala 429 | Glu 429 | conflict |
| Gln 594 | Arg 594 | conflict |
| Ala 657 | - | expression tag |
| Glu 658 | - | expression tag |
| Asn 659 | - | expression tag |
| Leu 660 | - | expression tag |
| Tyr 661 | - | expression tag |
| Phe 662 | - | expression tag |
| Gln 663 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 150922.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 3164.8 | |
| All* | Total formula weight | 154087.2 |
