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8QA6

MTHFR + SAM inhibited state

Functional Information from GO Data
ChainGOidnamespacecontents
A0001666biological_processresponse to hypoxia
A0001843biological_processneural tube closure
A0003824molecular_functioncatalytic activity
A0004489molecular_functionmethylenetetrahydrofolate reductase [NAD(P)H] activity
A0005515molecular_functionprotein binding
A0005829cellular_componentcytosol
A0006555biological_processmethionine metabolic process
A0009086biological_processmethionine biosynthetic process
A0009410biological_processresponse to xenobiotic stimulus
A0016491molecular_functionoxidoreductase activity
A0033274biological_processresponse to vitamin B2
A0035999biological_processtetrahydrofolate interconversion
A0043200biological_processresponse to amino acid
A0044877molecular_functionprotein-containing complex binding
A0046500biological_processS-adenosylmethionine metabolic process
A0046653biological_processtetrahydrofolate metabolic process
A0050660molecular_functionflavin adenine dinucleotide binding
A0050661molecular_functionNADP binding
A0050667biological_processhomocysteine metabolic process
A0051593biological_processresponse to folic acid
A0070555biological_processresponse to interleukin-1
A0070828biological_processheterochromatin organization
A0071949molecular_functionFAD binding
A0072341molecular_functionmodified amino acid binding
A0106313molecular_functionmethylenetetrahydrofolate reductase (NADPH) activity
B0001666biological_processresponse to hypoxia
B0001843biological_processneural tube closure
B0003824molecular_functioncatalytic activity
B0004489molecular_functionmethylenetetrahydrofolate reductase [NAD(P)H] activity
B0005515molecular_functionprotein binding
B0005829cellular_componentcytosol
B0006555biological_processmethionine metabolic process
B0009086biological_processmethionine biosynthetic process
B0009410biological_processresponse to xenobiotic stimulus
B0016491molecular_functionoxidoreductase activity
B0033274biological_processresponse to vitamin B2
B0035999biological_processtetrahydrofolate interconversion
B0043200biological_processresponse to amino acid
B0044877molecular_functionprotein-containing complex binding
B0046500biological_processS-adenosylmethionine metabolic process
B0046653biological_processtetrahydrofolate metabolic process
B0050660molecular_functionflavin adenine dinucleotide binding
B0050661molecular_functionNADP binding
B0050667biological_processhomocysteine metabolic process
B0051593biological_processresponse to folic acid
B0070555biological_processresponse to interleukin-1
B0070828biological_processheterochromatin organization
B0071949molecular_functionFAD binding
B0072341molecular_functionmodified amino acid binding
B0106313molecular_functionmethylenetetrahydrofolate reductase (NADPH) activity
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsActive site: {"description":"Proton donor/acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues20
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues40
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"29891918","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"29891918","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues4
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"29891918","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"29891918","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

239803

PDB entries from 2025-08-06

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