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8QA6

MTHFR + SAM inhibited state

Functional Information from GO Data
ChainGOidnamespacecontents
A0001666biological_processresponse to hypoxia
A0001843biological_processneural tube closure
A0004489molecular_functionmethylenetetrahydrofolate reductase (NAD(P)H) activity
A0005515molecular_functionprotein binding
A0005829cellular_componentcytosol
A0006555biological_processmethionine metabolic process
A0009086biological_processmethionine biosynthetic process
A0009410biological_processresponse to xenobiotic stimulus
A0016491molecular_functionoxidoreductase activity
A0033274biological_processresponse to vitamin B2
A0035999biological_processtetrahydrofolate interconversion
A0043200biological_processresponse to amino acid
A0044877molecular_functionprotein-containing complex binding
A0046500biological_processS-adenosylmethionine metabolic process
A0046653biological_processtetrahydrofolate metabolic process
A0050660molecular_functionflavin adenine dinucleotide binding
A0050661molecular_functionNADP binding
A0050667biological_processhomocysteine metabolic process
A0051593biological_processresponse to folic acid
A0070555biological_processresponse to interleukin-1
A0070828biological_processheterochromatin organization
A0071949molecular_functionFAD binding
A0072341molecular_functionmodified amino acid binding
A0106313molecular_functionmethylenetetrahydrofolate reductase (NADPH) activity
B0001666biological_processresponse to hypoxia
B0001843biological_processneural tube closure
B0004489molecular_functionmethylenetetrahydrofolate reductase (NAD(P)H) activity
B0005515molecular_functionprotein binding
B0005829cellular_componentcytosol
B0006555biological_processmethionine metabolic process
B0009086biological_processmethionine biosynthetic process
B0009410biological_processresponse to xenobiotic stimulus
B0016491molecular_functionoxidoreductase activity
B0033274biological_processresponse to vitamin B2
B0035999biological_processtetrahydrofolate interconversion
B0043200biological_processresponse to amino acid
B0044877molecular_functionprotein-containing complex binding
B0046500biological_processS-adenosylmethionine metabolic process
B0046653biological_processtetrahydrofolate metabolic process
B0050660molecular_functionflavin adenine dinucleotide binding
B0050661molecular_functionNADP binding
B0050667biological_processhomocysteine metabolic process
B0051593biological_processresponse to folic acid
B0070555biological_processresponse to interleukin-1
B0070828biological_processheterochromatin organization
B0071949molecular_functionFAD binding
B0072341molecular_functionmodified amino acid binding
B0106313molecular_functionmethylenetetrahydrofolate reductase (NADPH) activity
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton donor/acceptor => ECO:0000250
ChainResidueDetails
AGLU63
BGLU63

site_idSWS_FT_FI2
Number of Residues12
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AGLU63
BGLN228
BTYR321
BARG325
ATHR94
AASP159
AGLN228
ATYR321
AARG325
BGLU63
BTHR94
BASP159

site_idSWS_FT_FI3
Number of Residues24
DetailsBINDING: BINDING => ECO:0000269|PubMed:29891918
ChainResidueDetails
AHIS127
ATHR481
ATHR560
ATHR573
BHIS127
BARG157
BTYR174
BTYR197
BHIS201
BASP210
BLYS217
AARG157
BASN456
BALA461
BTHR481
BTHR560
BTHR573
ATYR174
ATYR197
AHIS201
AASP210
ALYS217
AASN456
AALA461

site_idSWS_FT_FI4
Number of Residues24
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:29891918
ChainResidueDetails
ASER9
ASER30
ASER103
ASER394
BSER9
BSER10
BSER18
BSER20
BSER21
BSER23
BSER25
ASER10
BSER26
BSER29
BSER30
BSER103
BSER394
ASER18
ASER20
ASER21
ASER23
ASER25
ASER26
ASER29

site_idSWS_FT_FI5
Number of Residues6
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:29891918
ChainResidueDetails
ATHR34
ATHR94
ATHR451
BTHR34
BTHR94
BTHR451

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000269|PubMed:29891918
ChainResidueDetails
ATYR90
BTYR90

222415

PDB entries from 2024-07-10

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