8Q9W
Crystal structure of HsRNMT complexed with sinefungin and GMP-PnP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | mRNA cap guanine-N7 methyltransferase | polymer | 276 | 32550.6 | 2 | UniProt (O43148) Pfam (PF03291) | Homo sapiens (human) | RG7MT1,mRNA (guanine-N(7))-methyltransferase,mRNA cap methyltransferase,hCMT1,hMet,hcm1p |
| 2 | C, E (A, B) | SINEFUNGIN | non-polymer | 381.4 | 2 | Chemie (SFG) PubChem (456189) PubChem (4065234) PubChem (6917665) PubChem (12771337) PubChem (25246236) PubChem (176612030) PubChem (177116271) PubChem (46875078) PubChem (46936257) PubChem (65482) PubChem (70789212) PubChem (93287274) PubChem (12771338) PubChem (70602121) PubChem (92403972) PubChem (93287270) PubChem (93287272) PubChem (93475589) PubChem (131971033) PubChem (131972810) PubChem (138626357) PubChem (156562738) PubChem (162866891) PubChem (163339130) PubChem (168280605) | |||
| 3 | D (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | F (B) | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 1 | Chemie (GNP) | |||
| 5 | G, H (A, B) | water | water | 18.0 | 103 | Chemie (HOH) |
Sequence modifications
A, B: 165 - 415 (UniProt: O43148)
A, B: 456 - 476 (UniProt: O43148)
A, B: 456 - 476 (UniProt: O43148)
| PDB | External Database | Details |
|---|---|---|
| Gly 416 | - | linker |
| Leu 417 | - | linker |
| Gly 418 | - | linker |
| Cys 419 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65101.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1381.0 | |
| All* | Total formula weight | 66482.2 |
