8Q8G

Crystal structure of HsRNMT complexed with inhibitor DDD1870799

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	mRNA cap guanine-N7 methyltransferase	polymer	276	32550.6	2	UniProt (O43148) Pfam (PF03291)	Homo sapiens (human)	RG7MT1,mRNA (guanine-N(7))-methyltransferase,mRNA cap methyltransferase,hCMT1,hMet,hcm1p
2	C, H (A, B)	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	2	Chemie (SAH) PubChem (193) PubChem (13792) PubChem (189149) PubChem (439155) PubChem (5284331) PubChem (71170554) PubChem (13231890) PubChem (16760024) PubChem (25210495) PubChem (44361184) PubChem (177678424) PubChem (46936206) PubChem (21125603) PubChem (25203782) PubChem (52224400) PubChem (50989525) PubChem (51380914) PubChem (52224398) PubChem (6419189) PubChem (57544532) PubChem (59046843) PubChem (59170628) PubChem (164157219) PubChem (59576228) PubChem (66805708) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (118374891) PubChem (118560068) PubChem (126969526) PubChem (129105892) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525)
3	D, I (A, B)	2-(4-fluorophenyl)-1-[(3~{S})-3-(6-oxidanyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)piperidin-1-yl]ethanone	non-polymer		354.4	2	Chemie (O94)
4	E, J, K (A, B)	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
5	F, G (A)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL) PubChem (753)
6	L, M (A, B)	water	water		18.0	108	Chemie (HOH)

Sequence modifications

A, B: 165 - 415 (UniProt: O43148)
A, B: 456 - 476 (UniProt: O43148)

PDB	External Database	Details
Gly 416	-	linker
Leu 417	-	linker
Gly 418	-	linker
Cys 419	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	65101.1
Non-Polymers*	Number of molecules	9
	Total formula weight	1950.0
All*	Total formula weight	67051.1

*Water molecules are not included.