8Q8G

Crystal structure of HsRNMT complexed with inhibitor DDD1870799

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
A	0006370	biological_process	7-methylguanosine mRNA capping
B	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
B	0006370	biological_process	7-methylguanosine mRNA capping

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00895","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00895","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27422871","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3BGV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E9J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E9W","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27422871","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3BGV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E9J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E9W","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Site: {"description":"mRNA cap binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00895","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---