8Q7O
Crystal structure of the FZD3 cysteine-rich domain in complex with a nanobody (14478)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Nanobody 14478 | polymer | 124 | 13264.6 | 2 | Lama glama | ||
| 2 | C, D (C, D) | Frizzled-3 | polymer | 124 | 14452.7 | 2 | UniProt (Q9NPG1) Pfam (PF01392) | Homo sapiens (human) | Fz-3,hFz3 |
| 3 | E, K (A, C) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 2 | Chemie (DMS) | |||
| 4 | F, J, L (B, C, D) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 5 | G (B) | CITRIC ACID | non-polymer | 192.1 | 1 | Chemie (CIT) | |||
| 6 | H, M (C, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 7 | I, N, O (C, D) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 8 | P, Q, R, S (A, B, C, D) | water | water | 18.0 | 207 | Chemie (HOH) |
Sequence modifications
C, D: 26 - 138 (UniProt: Q9NPG1)
| PDB | External Database | Details |
|---|---|---|
| Glu 23 | - | expression tag |
| Thr 24 | - | expression tag |
| Gly 25 | - | expression tag |
| Gly 139 | - | expression tag |
| Thr 140 | - | expression tag |
| Leu 141 | - | expression tag |
| Glu 142 | - | expression tag |
| Val 143 | - | expression tag |
| Leu 144 | - | expression tag |
| Phe 145 | - | expression tag |
| Gln 146 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 55434.6 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1355.3 | |
| All* | Total formula weight | 56789.9 |
