8Q6R

Structure of complement FP in complex with the TPP-3077 VHH

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	The properdin specific VHH TPP-3077	polymer	125	13804.4	2		Lama glama
2	C, E (C, E)	Properdin	polymer	108	11831.3	2	UniProt (P27918) Pfam (PF18487) Pfam (PF00090)	Homo sapiens (human)
3	D, F (D, F)	Properdin	polymer	221	24758.2	2	UniProt (P27918) Pfam (PF00090) Pfam (PF22195)	Homo sapiens (human)
4	G, H, J, K (G, H, J, K)	beta-D-glucopyranose-(1-3)-alpha-L-fucopyranose	branched		326.3	4	In PDB GlyTouCan (G36855WW)
5	I (I)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
6	L, M (A)	GLYCOCHOLIC ACID	non-polymer		465.6	2	Chemie (GCH)
7	AA, BA, CA, EA, FA... (F, C, D, E)	alpha-D-mannopyranose	non-polymer		180.2	20	Chemie (MAN)
8	DA (F)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
9	IA, JA, KA, LA, MA... (A, B, C, D, E...)	water	water		18.0	364	Chemie (HOH)

Sequence modifications

C, E: 28 - 135 (UniProt: P27918)

PDB	External Database	Details
Ala 132	Cys 132	conflict

D, F: 256 - 469 (UniProt: P27918)

PDB	External Database	Details
Gly 255	-	expression tag
His 470	-	expression tag
His 471	-	expression tag
His 472	-	expression tag
His 473	-	expression tag
His 474	-	expression tag
His 475	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	100787.8
Branched	Number of molecules	5
	Total formula weight	1729.6
Non-Polymers*	Number of molecules	23
	Total formula weight	4755.6
All*	Total formula weight	107272.9

*Water molecules are not included.