8Q6E
Aerobic crystal structure of HIF prolyl hydroxylase 2 (PHD2 181-407) in complex with Fe(III), 2-oxoglutarate (2OG) and HIF2alpha-CODD peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Egl nine homolog 1 | polymer | 233 | 26036.6 | 1 | UniProt (Q9GZT9) Pfam (PF13640) | Homo sapiens (human) | Hypoxia-inducible factor prolyl hydroxylase 2,HPH-2,Prolyl hydroxylase domain-containing protein 2,PHD2,SM-20 |
| 2 | B (B) | Endothelial PAS domain-containing protein 1 | polymer | 20 | 2309.5 | 1 | UniProt (Q99814) Pfam (PF11413) | Homo sapiens (human) | EPAS-1,Basic-helix-loop-helix-PAS protein MOP2,Class E basic helix-loop-helix protein 73,bHLHe73,HIF-1-alpha-like factor,HLF,Hypoxia-inducible factor 2-alpha,HIF-2-alpha,HIF2-alpha,Member of PAS protein 2,PAS domain-containing protein 2 |
| 3 | C, D, E (A) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 4 | F, G (A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | H (A) | FE (III) ION | non-polymer | 55.8 | 1 | Chemie (FE) | |||
| 6 | I (A) | 2-OXOGLUTARIC ACID | non-polymer | 146.1 | 1 | Chemie (AKG) | |||
| 7 | J, K (A, B) | water | water | 18.0 | 246 | Chemie (HOH) |
Sequence modifications
A: 181 - 407 (UniProt: Q9GZT9)
| PDB | External Database | Details |
|---|---|---|
| Gly 175 | - | expression tag |
| Ser 176 | - | expression tag |
| His 177 | - | expression tag |
| Met 178 | - | expression tag |
| Ala 179 | - | expression tag |
| Ser 180 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28346.1 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 345.8 | |
| All* | Total formula weight | 28691.9 |
