8PYR
Crystal structure of the dual T-loop phosphorylated Cdk7/CycH/Mat1 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E (A, E) | Cyclin-dependent kinase 7 | polymer | 346 | 39250.3 | 2 | UniProt (P50613) Pfam (PF00069) | Homo sapiens (human) | 39 kDa protein kinase,p39 Mo15,CDK-activating kinase 1,Cell division protein kinase 7,Serine/threonine-protein kinase 1,TFIIH basal transcription factor complex kinase subunit |
| 2 | B, F (B, F) | Cyclin-H | polymer | 323 | 37695.5 | 2 | UniProt (P51946) Pfam (PF00134) Pfam (PF16899) | Homo sapiens (human) | MO15-associated protein,p34,p37 |
| 3 | C, G (C, G) | CDK-activating kinase assembly factor MAT1 | polymer | 82 | 9043.1 | 2 | UniProt (P51948) | Homo sapiens (human) | CDK7/cyclin-H assembly factor,Cyclin-G1-interacting protein,Menage a trois,RING finger protein 66,RING finger protein MAT1,p35,p36 |
| 4 | D, H (D, H) | Nanobody (VHH-RD7-04) | polymer | 115 | 12443.9 | 2 | Lama glama | ||
| 5 | I, J, K, L, M... (A, B, E) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 6 | Chemie (EDO) | |||
| 6 | O, P, Q, R, S... (A, B, C, D, E...) | water | water | 18.0 | 384 | Chemie (HOH) |
Sequence modifications
C, G: 230 - 309 (UniProt: P51948)
| PDB | External Database | Details |
|---|---|---|
| Gly 228 | - | expression tag |
| Ser 229 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 196865.5 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 372.4 | |
| All* | Total formula weight | 197237.9 |
