Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8PYR

Crystal structure of the dual T-loop phosphorylated Cdk7/CycH/Mat1 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000439	cellular_component	transcription factor TFIIH core complex
A	0001650	cellular_component	fibrillar center
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004693	molecular_function	cyclin-dependent protein serine/threonine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005675	cellular_component	transcription factor TFIIH holo complex
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006281	biological_process	DNA repair
A	0006289	biological_process	nucleotide-excision repair
A	0006351	biological_process	DNA-templated transcription
A	0006366	biological_process	transcription by RNA polymerase II
A	0006367	biological_process	transcription initiation at RNA polymerase II promoter
A	0006468	biological_process	protein phosphorylation
A	0006974	biological_process	DNA damage response
A	0008094	molecular_function	ATP-dependent activity, acting on DNA
A	0008353	molecular_function	RNA polymerase II CTD heptapeptide repeat kinase activity
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0042795	biological_process	snRNA transcription by RNA polymerase II
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0050821	biological_process	protein stabilization
A	0051301	biological_process	cell division
A	0051726	biological_process	regulation of cell cycle
A	0070516	cellular_component	CAK-ERCC2 complex
A	0070985	cellular_component	transcription factor TFIIK complex
A	0106310	molecular_function	protein serine kinase activity
A	0140836	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 kinase activity
A	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
B	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
B	0000439	cellular_component	transcription factor TFIIH core complex
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005675	cellular_component	transcription factor TFIIH holo complex
B	0006289	biological_process	nucleotide-excision repair
B	0006351	biological_process	DNA-templated transcription
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0006367	biological_process	transcription initiation at RNA polymerase II promoter
B	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
B	0016301	molecular_function	kinase activity
B	0016538	molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity
B	0050821	biological_process	protein stabilization
B	0070516	cellular_component	CAK-ERCC2 complex
B	0070985	cellular_component	transcription factor TFIIK complex
B	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
E	0000166	molecular_function	nucleotide binding
E	0000439	cellular_component	transcription factor TFIIH core complex
E	0001650	cellular_component	fibrillar center
E	0004672	molecular_function	protein kinase activity
E	0004674	molecular_function	protein serine/threonine kinase activity
E	0004693	molecular_function	cyclin-dependent protein serine/threonine kinase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005675	cellular_component	transcription factor TFIIH holo complex
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006281	biological_process	DNA repair
E	0006289	biological_process	nucleotide-excision repair
E	0006351	biological_process	DNA-templated transcription
E	0006366	biological_process	transcription by RNA polymerase II
E	0006367	biological_process	transcription initiation at RNA polymerase II promoter
E	0006468	biological_process	protein phosphorylation
E	0006974	biological_process	DNA damage response
E	0008094	molecular_function	ATP-dependent activity, acting on DNA
E	0008353	molecular_function	RNA polymerase II CTD heptapeptide repeat kinase activity
E	0016301	molecular_function	kinase activity
E	0016740	molecular_function	transferase activity
E	0042795	biological_process	snRNA transcription by RNA polymerase II
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0050821	biological_process	protein stabilization
E	0051301	biological_process	cell division
E	0051726	biological_process	regulation of cell cycle
E	0070516	cellular_component	CAK-ERCC2 complex
E	0070985	cellular_component	transcription factor TFIIK complex
E	0106310	molecular_function	protein serine kinase activity
E	0140836	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 kinase activity
E	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
F	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
F	0000439	cellular_component	transcription factor TFIIH core complex
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005675	cellular_component	transcription factor TFIIH holo complex
F	0006289	biological_process	nucleotide-excision repair
F	0006351	biological_process	DNA-templated transcription
F	0006357	biological_process	regulation of transcription by RNA polymerase II
F	0006367	biological_process	transcription initiation at RNA polymerase II promoter
F	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
F	0016301	molecular_function	kinase activity
F	0016538	molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity
F	0050821	biological_process	protein stabilization
F	0070516	cellular_component	CAK-ERCC2 complex
F	0070985	cellular_component	transcription factor TFIIK complex
F	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	25
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGQFATVYkArdkntnqiv.........AIKK

Chain	Residue	Details
A	LEU18-LYS42

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IlHrDLKpnNLLL

Chain	Residue	Details
A	ILE133-LEU145

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15530371","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by CDK1 and CDK2","evidences":[{"source":"PubMed","id":"11113184","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9832506","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by CDK2","evidences":[{"source":"PubMed","id":"11113184","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15530371","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9832506","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by CDK8","evidences":[{"source":"PubMed","id":"10993082","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)