8PWC
Crystal structure of MDM2 with Brigimadlin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | E3 ubiquitin-protein ligase Mdm2 | polymer | 110 | 12592.4 | 3 | UniProt (Q00987) Pfam (PF02201) | Homo sapiens (human) | Double minute 2 protein,Hdm2,Oncoprotein Mdm2,RING-type E3 ubiquitin transferase Mdm2,p53-binding protein Mdm2 |
| 2 | D, E, F (A, B, C) | Brigimadlin | non-polymer | 591.5 | 3 | Chemie (G7I) | |||
| 3 | G, H, I (A, B, C) | water | water | 18.0 | 215 | Chemie (HOH) |
Sequence modifications
A, B, C: 17 - 125 (UniProt: Q00987)
| PDB | External Database | Details |
|---|---|---|
| Gly 16 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 37777.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1774.4 | |
| All* | Total formula weight | 39551.6 |
