8PTZ
Cryo-EM structure of human Elp123 in complex with tRNA, S-ethyl-CoA, 5'-deoxyadenosine and methionine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Elongator complex protein 1 | polymer | 1332 | 150427.5 | 1 | UniProt (O95163) Pfam (PF04762) Pfam (PF23797) Pfam (PF23925) Pfam (PF23878) Pfam (PF23936) | Homo sapiens (human) | ELP1,IkappaB kinase complex-associated protein,IKK complex-associated protein,p150 |
| 2 | B (B) | Elongator complex protein 2 | polymer | 826 | 92597.8 | 1 | UniProt (Q6IA86) Pfam (PF00400) | Homo sapiens (human) | ELP2,SHINC-2,STAT3-interacting protein 1,StIP1 |
| 3 | C (C) | Elongator complex protein 3 | polymer | 581 | 65740.5 | 1 | UniProt (Q9H9T3) Pfam (PF23613) Pfam (PF04055) Pfam (PF16199) | Homo sapiens (human) | hELP3,tRNA uridine(34) acetyltransferase |
| 4 | D (X) | tRNA Gln | polymer | 75 | 24047.2 | 1 | Homo sapiens | ||
| 5 | E (C) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 1 | Chemie (SF4) | |||
| 6 | F (C) | 5'-DEOXYADENOSINE | non-polymer | 251.2 | 1 | Chemie (5AD) | |||
| 7 | G (C) | S-Ethyl-CoA | non-polymer | 795.6 | 1 | Chemie (A2U) | |||
| 8 | H (C) | METHIONINE | non-polymer | 149.2 | 1 | Chemie (MET) | |||
| 9 | I, J (X) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) |
Sequence modifications
C: 1 - 547 (UniProt: Q9H9T3)
| PDB | External Database | Details |
|---|---|---|
| Gly 548 | - | expression tag |
| Leu 549 | - | expression tag |
| Glu 550 | - | expression tag |
| Gly 551 | - | expression tag |
| Ser 552 | - | expression tag |
| Ala 553 | - | expression tag |
| Trp 554 | - | expression tag |
| Ser 555 | - | expression tag |
| His 556 | - | expression tag |
| Pro 557 | - | expression tag |
| Gln 558 | - | expression tag |
| Phe 559 | - | expression tag |
| Glu 560 | - | expression tag |
| Lys 561 | - | expression tag |
| Gly 562 | - | expression tag |
| Gly 563 | - | expression tag |
| Gly 564 | - | expression tag |
| Ser 565 | - | expression tag |
| Gly 566 | - | expression tag |
| Gly 567 | - | expression tag |
| Gly 568 | - | expression tag |
| Ser 569 | - | expression tag |
| Gly 570 | - | expression tag |
| Gly 571 | - | expression tag |
| Ser 572 | - | expression tag |
| Ala 573 | - | expression tag |
| Trp 574 | - | expression tag |
| Ser 575 | - | expression tag |
| His 576 | - | expression tag |
| Pro 577 | - | expression tag |
| Gln 578 | - | expression tag |
| Phe 579 | - | expression tag |
| Glu 580 | - | expression tag |
| Lys 581 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 332813.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1596.3 | |
| All* | Total formula weight | 334409.3 |
