8PTZ

Cryo-EM structure of human Elp123 in complex with tRNA, S-ethyl-CoA, 5'-deoxyadenosine and methionine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000049	molecular_function	tRNA binding
A	0002098	biological_process	tRNA wobble uridine modification
A	0002926	biological_process	tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006417	biological_process	regulation of translation
A	0008033	biological_process	tRNA processing
A	0033588	cellular_component	elongator holoenzyme complex
B	0000993	molecular_function	RNA polymerase II complex binding
B	0002098	biological_process	tRNA wobble uridine modification
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0006368	biological_process	transcription elongation by RNA polymerase II
B	0006417	biological_process	regulation of translation
B	0008023	cellular_component	transcription elongation factor complex
B	0008033	biological_process	tRNA processing
B	0019901	molecular_function	protein kinase binding
B	0033588	cellular_component	elongator holoenzyme complex
B	0046425	biological_process	regulation of receptor signaling pathway via JAK-STAT
C	0000049	molecular_function	tRNA binding
C	0001764	biological_process	neuron migration
C	0002098	biological_process	tRNA wobble uridine modification
C	0002926	biological_process	tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0006417	biological_process	regulation of translation
C	0007399	biological_process	nervous system development
C	0007417	biological_process	central nervous system development
C	0008033	biological_process	tRNA processing
C	0008607	molecular_function	phosphorylase kinase regulator activity
C	0016407	molecular_function	acetyltransferase activity
C	0016746	molecular_function	acyltransferase activity
C	0030335	biological_process	positive regulation of cell migration
C	0033588	cellular_component	elongator holoenzyme complex
C	0046872	molecular_function	metal ion binding
C	0051539	molecular_function	4 iron, 4 sulfur cluster binding
C	0106261	molecular_function	tRNA uridine(34) acetyltransferase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q02908

Chain	Residue	Details
C	CYS99
C	CYS109
C	CYS112

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250|UniProtKB:A0A1C7D1B7

Chain	Residue	Details
C	LYS164
C	GLU474
C	PHE497
C	TYR530

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9CZX0

Chain	Residue	Details
C	SER161
A	SER1174

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by ALK => ECO:0000269|PubMed:31341009, ECO:0007744|PubMed:15592455

Chain	Residue	Details
C	TYR202

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N6-methyllysine => ECO:0007744|PubMed:24129315

Chain	Residue	Details
C	LYS229

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site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:31341009

Chain	Residue	Details
C	TYR251

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