8PR1

Cytoplasmic dynein-B heavy chain bound to IC-LC tower

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (D, E)	Dynein light chain 1, cytoplasmic	polymer	89	10381.9	2	UniProt (P63167) Pfam (PF01221)	Homo sapiens (human)	8 kDa dynein light chain,DLC8,Dynein light chain LC8-type 1,Protein inhibitor of neuronal nitric oxide synthase,PIN
2	C, D (I, J)	Cytoplasmic dynein 1 intermediate chain 2	polymer	612	68442.1	2	UniProt (Q13409) Pfam (PF11540) Pfam (PF00400)	Homo sapiens (human)	Cytoplasmic dynein intermediate chain 2,Dynein intermediate chain 2,cytosolic,DH IC-2
3	E, F (K, L)	Dynein light chain Tctex-type 1	polymer	113	12462.0	2	UniProt (P63172) Pfam (PF03645)	Homo sapiens (human)
4	G, I (A, G)	Cytoplasmic dynein 1 heavy chain 1	polymer	4646	533055.1	2	UniProt (Q14204) Pfam (PF08385) Pfam (PF03028) Pfam (PF18198) Pfam (PF18199) Pfam (PF08393) Pfam (PF12774) Pfam (PF17852) Pfam (PF12775) Pfam (PF22597) Pfam (PF12780) Pfam (PF12777) Pfam (PF12781)	Homo sapiens (human)	Cytoplasmic dynein heavy chain 1,Dynein heavy chain,cytosolic
5	H, J (F, H)	Cytoplasmic dynein 1 light intermediate chain 2	polymer	492	54173.2	2	UniProt (O43237) Pfam (PF05783)	Homo sapiens (human)	Dynein light intermediate chain 2,cytosolic,LIC-2,LIC53/55
6	K, L (t, s)	Dynein light chain roadblock-type 1	polymer	96	10934.6	2	UniProt (Q9NP97) Pfam (PF03259)	Homo sapiens (human)	Bithoraxoid-like protein,BLP,Dynein light chain 2A,cytoplasmic,Dynein-associated protein Km23,Roadblock domain-containing protein 1

Sequence modifications

I, J: 1 - 612 (UniProt: Q13409)

PDB	External Database	Details
Ser 484	Thr 484	conflict
Gly 499	Asp 499	conflict

A, G: 1 - 4646 (UniProt: Q14204)

PDB	External Database	Details
Glu 1567	Arg 1567	engineered mutation
Glu 1610	Lys 1610	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	1378897.8
All*	Total formula weight	1378897.8

*Water molecules are not included.