8PR1

Cytoplasmic dynein-B heavy chain bound to IC-LC tower

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001673	cellular_component	male germ cell nucleus
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005813	cellular_component	centrosome
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005868	cellular_component	cytoplasmic dynein complex
A	0005874	cellular_component	microtubule
A	0005881	cellular_component	cytoplasmic microtubule
A	0005938	cellular_component	cell cortex
A	0007018	biological_process	microtubule-based movement
A	0007052	biological_process	mitotic spindle organization
A	0007097	biological_process	nuclear migration
A	0008090	biological_process	retrograde axonal transport
A	0008569	molecular_function	minus-end-directed microtubule motor activity
A	0016020	cellular_component	membrane
A	0030175	cellular_component	filopodium
A	0030286	cellular_component	dynein complex
A	0031122	biological_process	cytoplasmic microtubule organization
A	0032388	biological_process	positive regulation of intracellular transport
A	0033962	biological_process	P-body assembly
A	0034063	biological_process	stress granule assembly
A	0035578	cellular_component	azurophil granule lumen
A	0042802	molecular_function	identical protein binding
A	0045505	molecular_function	dynein intermediate chain binding
A	0051293	biological_process	establishment of spindle localization
A	0051301	biological_process	cell division
A	0051959	molecular_function	dynein light intermediate chain binding
A	0060236	biological_process	regulation of mitotic spindle organization
A	0070062	cellular_component	extracellular exosome
A	0090235	biological_process	regulation of metaphase plate congression
A	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
A	0120162	biological_process	positive regulation of cold-induced thermogenesis
A	1904115	cellular_component	axon cytoplasm
A	1905832	biological_process	positive regulation of spindle assembly
D	0000776	cellular_component	kinetochore
D	0001673	cellular_component	male germ cell nucleus
D	0004857	molecular_function	enzyme inhibitor activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005694	cellular_component	chromosome
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005813	cellular_component	centrosome
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0005868	cellular_component	cytoplasmic dynein complex
D	0005874	cellular_component	microtubule
D	0005875	cellular_component	microtubule associated complex
D	0005886	cellular_component	plasma membrane
D	0005929	cellular_component	cilium
D	0006351	biological_process	DNA-templated transcription
D	0006915	biological_process	apoptotic process
D	0006974	biological_process	DNA damage response
D	0007017	biological_process	microtubule-based process
D	0007286	biological_process	spermatid development
D	0008180	cellular_component	COP9 signalosome
D	0015630	cellular_component	microtubule cytoskeleton
D	0016020	cellular_component	membrane
D	0019899	molecular_function	enzyme binding
D	0021762	biological_process	substantia nigra development
D	0030141	cellular_component	secretory granule
D	0030235	molecular_function	nitric-oxide synthase regulator activity
D	0030286	cellular_component	dynein complex
D	0032388	biological_process	positive regulation of intracellular transport
D	0035721	biological_process	intraciliary retrograde transport
D	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
D	0035861	cellular_component	site of double-strand break
D	0036487	molecular_function	nitric-oxide synthase inhibitor activity
D	0042326	biological_process	negative regulation of phosphorylation
D	0042802	molecular_function	identical protein binding
D	0044458	biological_process	motile cilium assembly
D	0044877	molecular_function	protein-containing complex binding
D	0045505	molecular_function	dynein intermediate chain binding
D	0070821	cellular_component	tertiary granule membrane
D	0072686	cellular_component	mitotic spindle
D	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
D	0097110	molecular_function	scaffold protein binding
D	0097542	cellular_component	ciliary tip
D	0101003	cellular_component	ficolin-1-rich granule membrane
D	0110027	biological_process	negative regulation of DNA strand resection involved in replication fork processing
D	1904115	cellular_component	axon cytoplasm
E	0000776	cellular_component	kinetochore
E	0001673	cellular_component	male germ cell nucleus
E	0004857	molecular_function	enzyme inhibitor activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005694	cellular_component	chromosome
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005813	cellular_component	centrosome
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005868	cellular_component	cytoplasmic dynein complex
E	0005874	cellular_component	microtubule
E	0005875	cellular_component	microtubule associated complex
E	0005886	cellular_component	plasma membrane
E	0005929	cellular_component	cilium
E	0006351	biological_process	DNA-templated transcription
E	0006915	biological_process	apoptotic process
E	0006974	biological_process	DNA damage response
E	0007017	biological_process	microtubule-based process
E	0007286	biological_process	spermatid development
E	0008180	cellular_component	COP9 signalosome
E	0015630	cellular_component	microtubule cytoskeleton
E	0016020	cellular_component	membrane
E	0019899	molecular_function	enzyme binding
E	0021762	biological_process	substantia nigra development
E	0030141	cellular_component	secretory granule
E	0030235	molecular_function	nitric-oxide synthase regulator activity
E	0030286	cellular_component	dynein complex
E	0032388	biological_process	positive regulation of intracellular transport
E	0035721	biological_process	intraciliary retrograde transport
E	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
E	0035861	cellular_component	site of double-strand break
E	0036487	molecular_function	nitric-oxide synthase inhibitor activity
E	0042326	biological_process	negative regulation of phosphorylation
E	0042802	molecular_function	identical protein binding
E	0044458	biological_process	motile cilium assembly
E	0044877	molecular_function	protein-containing complex binding
E	0045505	molecular_function	dynein intermediate chain binding
E	0070821	cellular_component	tertiary granule membrane
E	0072686	cellular_component	mitotic spindle
E	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
E	0097110	molecular_function	scaffold protein binding
E	0097542	cellular_component	ciliary tip
E	0101003	cellular_component	ficolin-1-rich granule membrane
E	0110027	biological_process	negative regulation of DNA strand resection involved in replication fork processing
E	1904115	cellular_component	axon cytoplasm
F	0000166	molecular_function	nucleotide binding
F	0000226	biological_process	microtubule cytoskeleton organization
F	0000776	cellular_component	kinetochore
F	0001673	cellular_component	male germ cell nucleus
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005770	cellular_component	late endosome
F	0005813	cellular_component	centrosome
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0005868	cellular_component	cytoplasmic dynein complex
F	0005874	cellular_component	microtubule
F	0007018	biological_process	microtubule-based movement
F	0016020	cellular_component	membrane
F	0030286	cellular_component	dynein complex
F	0032388	biological_process	positive regulation of intracellular transport
F	0042802	molecular_function	identical protein binding
F	0045504	molecular_function	dynein heavy chain binding
F	1990090	biological_process	cellular response to nerve growth factor stimulus
G	0000166	molecular_function	nucleotide binding
G	0001673	cellular_component	male germ cell nucleus
G	0003723	molecular_function	RNA binding
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005576	cellular_component	extracellular region
G	0005737	cellular_component	cytoplasm
G	0005813	cellular_component	centrosome
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0005868	cellular_component	cytoplasmic dynein complex
G	0005874	cellular_component	microtubule
G	0005881	cellular_component	cytoplasmic microtubule
G	0005938	cellular_component	cell cortex
G	0007018	biological_process	microtubule-based movement
G	0007052	biological_process	mitotic spindle organization
G	0007097	biological_process	nuclear migration
G	0008090	biological_process	retrograde axonal transport
G	0008569	molecular_function	minus-end-directed microtubule motor activity
G	0016020	cellular_component	membrane
G	0030175	cellular_component	filopodium
G	0030286	cellular_component	dynein complex
G	0031122	biological_process	cytoplasmic microtubule organization
G	0032388	biological_process	positive regulation of intracellular transport
G	0033962	biological_process	P-body assembly
G	0034063	biological_process	stress granule assembly
G	0035578	cellular_component	azurophil granule lumen
G	0042802	molecular_function	identical protein binding
G	0045505	molecular_function	dynein intermediate chain binding
G	0051293	biological_process	establishment of spindle localization
G	0051301	biological_process	cell division
G	0051959	molecular_function	dynein light intermediate chain binding
G	0060236	biological_process	regulation of mitotic spindle organization
G	0070062	cellular_component	extracellular exosome
G	0090235	biological_process	regulation of metaphase plate congression
G	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
G	0120162	biological_process	positive regulation of cold-induced thermogenesis
G	1904115	cellular_component	axon cytoplasm
G	1905832	biological_process	positive regulation of spindle assembly
H	0000166	molecular_function	nucleotide binding
H	0000226	biological_process	microtubule cytoskeleton organization
H	0000776	cellular_component	kinetochore
H	0001673	cellular_component	male germ cell nucleus
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005770	cellular_component	late endosome
H	0005813	cellular_component	centrosome
H	0005829	cellular_component	cytosol
H	0005856	cellular_component	cytoskeleton
H	0005868	cellular_component	cytoplasmic dynein complex
H	0005874	cellular_component	microtubule
H	0007018	biological_process	microtubule-based movement
H	0016020	cellular_component	membrane
H	0030286	cellular_component	dynein complex
H	0032388	biological_process	positive regulation of intracellular transport
H	0042802	molecular_function	identical protein binding
H	0045504	molecular_function	dynein heavy chain binding
H	1990090	biological_process	cellular response to nerve growth factor stimulus
I	0001673	cellular_component	male germ cell nucleus
I	0003777	molecular_function	microtubule motor activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005813	cellular_component	centrosome
I	0005829	cellular_component	cytosol
I	0005856	cellular_component	cytoskeleton
I	0005868	cellular_component	cytoplasmic dynein complex
I	0005874	cellular_component	microtubule
I	0007018	biological_process	microtubule-based movement
I	0010970	biological_process	transport along microtubule
I	0030286	cellular_component	dynein complex
I	0031982	cellular_component	vesicle
I	0032388	biological_process	positive regulation of intracellular transport
I	0045503	molecular_function	dynein light chain binding
I	0045504	molecular_function	dynein heavy chain binding
I	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
J	0001673	cellular_component	male germ cell nucleus
J	0003777	molecular_function	microtubule motor activity
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0005813	cellular_component	centrosome
J	0005829	cellular_component	cytosol
J	0005856	cellular_component	cytoskeleton
J	0005868	cellular_component	cytoplasmic dynein complex
J	0005874	cellular_component	microtubule
J	0007018	biological_process	microtubule-based movement
J	0010970	biological_process	transport along microtubule
J	0030286	cellular_component	dynein complex
J	0031982	cellular_component	vesicle
J	0032388	biological_process	positive regulation of intracellular transport
J	0045503	molecular_function	dynein light chain binding
J	0045504	molecular_function	dynein heavy chain binding
J	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
K	0000132	biological_process	establishment of mitotic spindle orientation
K	0001673	cellular_component	male germ cell nucleus
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005737	cellular_component	cytoplasm
K	0005794	cellular_component	Golgi apparatus
K	0005819	cellular_component	spindle
K	0005868	cellular_component	cytoplasmic dynein complex
K	0005874	cellular_component	microtubule
K	0005881	cellular_component	cytoplasmic microtubule
K	0005929	cellular_component	cilium
K	0007018	biological_process	microtubule-based movement
K	0007399	biological_process	nervous system development
K	0008277	biological_process	regulation of G protein-coupled receptor signaling pathway
K	0019060	biological_process	intracellular transport of viral protein in host cell
K	0030286	cellular_component	dynein complex
K	0032388	biological_process	positive regulation of intracellular transport
K	0034774	cellular_component	secretory granule lumen
K	0035721	biological_process	intraciliary retrograde transport
K	0042802	molecular_function	identical protein binding
K	0043657	cellular_component	host cell
K	0045505	molecular_function	dynein intermediate chain binding
K	0046718	biological_process	symbiont entry into host cell
K	0050768	biological_process	negative regulation of neurogenesis
K	0051301	biological_process	cell division
K	0075521	biological_process	microtubule-dependent intracellular transport of viral material towards nucleus
K	0075606	biological_process	transport of viral material towards nucleus
K	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
K	0099503	cellular_component	secretory vesicle
K	1904813	cellular_component	ficolin-1-rich granule lumen
L	0000132	biological_process	establishment of mitotic spindle orientation
L	0001673	cellular_component	male germ cell nucleus
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005737	cellular_component	cytoplasm
L	0005794	cellular_component	Golgi apparatus
L	0005819	cellular_component	spindle
L	0005868	cellular_component	cytoplasmic dynein complex
L	0005874	cellular_component	microtubule
L	0005881	cellular_component	cytoplasmic microtubule
L	0005929	cellular_component	cilium
L	0007018	biological_process	microtubule-based movement
L	0007399	biological_process	nervous system development
L	0008277	biological_process	regulation of G protein-coupled receptor signaling pathway
L	0019060	biological_process	intracellular transport of viral protein in host cell
L	0030286	cellular_component	dynein complex
L	0032388	biological_process	positive regulation of intracellular transport
L	0034774	cellular_component	secretory granule lumen
L	0035721	biological_process	intraciliary retrograde transport
L	0042802	molecular_function	identical protein binding
L	0043657	cellular_component	host cell
L	0045505	molecular_function	dynein intermediate chain binding
L	0046718	biological_process	symbiont entry into host cell
L	0050768	biological_process	negative regulation of neurogenesis
L	0051301	biological_process	cell division
L	0075521	biological_process	microtubule-dependent intracellular transport of viral material towards nucleus
L	0075606	biological_process	transport of viral material towards nucleus
L	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
L	0099503	cellular_component	secretory vesicle
L	1904813	cellular_component	ficolin-1-rich granule lumen
s	0003777	molecular_function	microtubule motor activity
s	0005515	molecular_function	protein binding
s	0005737	cellular_component	cytoplasm
s	0005813	cellular_component	centrosome
s	0005856	cellular_component	cytoskeleton
s	0005868	cellular_component	cytoplasmic dynein complex
s	0005874	cellular_component	microtubule
s	0005929	cellular_component	cilium
s	0007018	biological_process	microtubule-based movement
s	0007632	biological_process	visual behavior
s	0016020	cellular_component	membrane
s	0030286	cellular_component	dynein complex
s	0032388	biological_process	positive regulation of intracellular transport
s	0035721	biological_process	intraciliary retrograde transport
s	0042802	molecular_function	identical protein binding
s	0045505	molecular_function	dynein intermediate chain binding
s	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
s	0097542	cellular_component	ciliary tip
t	0003777	molecular_function	microtubule motor activity
t	0005515	molecular_function	protein binding
t	0005737	cellular_component	cytoplasm
t	0005813	cellular_component	centrosome
t	0005856	cellular_component	cytoskeleton
t	0005868	cellular_component	cytoplasmic dynein complex
t	0005874	cellular_component	microtubule
t	0005929	cellular_component	cilium
t	0007018	biological_process	microtubule-based movement
t	0007632	biological_process	visual behavior
t	0016020	cellular_component	membrane
t	0030286	cellular_component	dynein complex
t	0032388	biological_process	positive regulation of intracellular transport
t	0035721	biological_process	intraciliary retrograde transport
t	0042802	molecular_function	identical protein binding
t	0045505	molecular_function	dynein intermediate chain binding
t	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
t	0097542	cellular_component	ciliary tip

Functional Information from PROSITE/UniProt

site_id	PS00639
Number of Residues	11
Details	THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. INHGLMMVGPS

Chain	Residue	Details
A	ILE2216-SER2226

---

site_id	PS01239
Number of Residues	15
Details	DYNEIN_LIGHT_1 Dynein light chain type 1 signature. HcIvGRnFGSyVTHE

Chain	Residue	Details
D	HIS55-GLU69

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	44
Details	Region: {"description":"Interaction with ESR1","evidences":[{"source":"PubMed","id":"15891768","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"15193260","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30464262","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37696958","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	98
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	80
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	82
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	80
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	90
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	80
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	78
Details	Repeat: {"description":"WD 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	144
Details	Region: {"description":"Interaction with GNB1","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	208
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9JHU4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	38
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	14
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---