8PPA
Human inositol 1,4,5-trisphosphate 3-kinase A (IP3K) catalytic domain in complex with D-myo-inositol 1,4,6-trisphosphate/AMP-PNP/Mn
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Inositol-trisphosphate 3-kinase A | polymer | 279 | 31877.3 | 2 | UniProt (P23677) Pfam (PF03770) | Homo sapiens (human) | Inositol 1,4,5-trisphosphate 3-kinase A,IP3 3-kinase A,IP3K A,InsP 3-kinase A |
| 2 | C, J (A, B) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 2 | Chemie (ANP) | |||
| 3 | D, K (A, B) | D-myo-inositol 1,4,6-trisphosphate | non-polymer | 420.1 | 2 | Chemie (06G) | |||
| 4 | E, F, G, L, M... (A, B) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 5 | H, I (A) | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
| 6 | O, P (A, B) | water | water | 18.0 | 371 | Chemie (HOH) |
Sequence modifications
A, B: 188 - 461 (UniProt: P23677)
| PDB | External Database | Details |
|---|---|---|
| Gly 183 | - | expression tag |
| Ser 184 | - | expression tag |
| His 185 | - | expression tag |
| Met 186 | - | expression tag |
| Ser 187 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 63754.5 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2538.8 | |
| All* | Total formula weight | 66293.4 |
