8PM2
Structure of the murine trace amine-associated receptor TAAR7f bound to N,N-dimethylcyclohexylamine (DMCH) in complex with mini-Gs trimeric G protein
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 249 | 28964.7 | 1 | Pfam (PF00503) UniProt (by SIFTS) (P63092) | Homo sapiens (human) | |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 340 | 37342.8 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | |
| 3 | C (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7845.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 4 | D (N) | Nanobody 35 | polymer | 156 | 16926.1 | 1 | Lama glama | ||
| 5 | E (R) | Trace amine-associated receptor 7f | polymer | 365 | 41012.5 | 1 | UniProt (Q5QD08) Pfam (PF00001) | Mus musculus (house mouse) | TaR-7f,Trace amine receptor 7f,mTaar7f |
| 6 | F (R) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 1 | Chemie (Y01) PubChem (16219150) PubChem (22210610) PubChem (45489984) PubChem (60078761) PubChem (73440805) PubChem (99567469) PubChem (124301053) PubChem (124302591) PubChem (124303794) PubChem (124421343) PubChem (124427195) PubChem (124914595) PubChem (124914596) PubChem (131705526) PubChem (137332121) PubChem (137496357) PubChem (146157332) PubChem (154929912) PubChem (155199678) PubChem (156327905) PubChem (156426247) PubChem (156516588) PubChem (166979870) PubChem (167024614) PubChem (169132513) PubChem (170117245) PubChem (172400028) PubChem (57163942) PubChem (89891013) PubChem (99567468) PubChem (124427194) PubChem (124897021) PubChem (124897020) PubChem (10005657) PubChem (130340716) PubChem (11969853) PubChem (137392566) PubChem (137496323) PubChem (155804219) PubChem (169132514) PubChem (65082) PubChem (363416) PubChem (500055) PubChem (13301926) PubChem (13301927) | |||
| 7 | G (R) | ~{N},~{N}-dimethylcyclohexanamine | non-polymer | 127.2 | 1 | Chemie (8IA) PubChem (7415) |
Sequence modifications
B: 2 - 340 (UniProt: P62873)
G: 1 - 71 (UniProt: P59768)
R: 1 - 358 (UniProt: Q5QD08)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 68 | Cys 68 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
| Leu 359 | - | expression tag |
| Glu 360 | - | expression tag |
| Val 361 | - | expression tag |
| Leu 362 | - | expression tag |
| Phe 363 | - | expression tag |
| Gln 364 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 132091.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 614.0 | |
| All* | Total formula weight | 132705.2 |
