8PJO
Cryo EM structure of the type 3D polymorph of alpha-synuclein E46K mutant at low pH.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Alpha-synuclein | polymer | 140 | 14476.2 | 10 | UniProt (P37840) Pfam (PF01387) | Homo sapiens (human) | Non-A beta component of AD amyloid,Non-A4 component of amyloid precursor,NACP |
| 2 | K, L, M, N, O... (A, B, C, D, E...) | CHLORIDE ION | non-polymer | 35.5 | 10 | Chemie (CL) | |||
| 3 | AA, BA, CA, DA, U... (G, H, I, J, A...) | water | water | 18.0 | 100 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J: 1 - 140 (UniProt: P37840)
| PDB | External Database | Details |
|---|---|---|
| Lys 46 | Glu 46 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 144761.8 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 354.5 | |
| All* | Total formula weight | 145116.3 |
