8PHV

Structure of Human selenomethionylated Cdc123 bound to domain 3 of eIF2 gamma

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Cell division cycle protein 123 homolog	polymer	356	41489.7	2	UniProt (O75794) Pfam (PF07065)	Homo sapiens (human)	Protein D123,HT-1080,PZ32
2	B, D (B, D)	Eukaryotic translation initiation factor 2 subunit 3	polymer	111	12443.3	2	UniProt (P41091) Pfam (PF09173)	Homo sapiens (human)	Eukaryotic translation initiation factor 2 subunit gamma X,eIF-2-gamma X,eIF-2gX
3	E, F (A, C)	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	2	Chemie (ATP)
4	G, H, I, J (A, B, C, D)	water	water		18.0	195	Chemie (HOH)

Sequence modifications

A, C: 1 - 336 (UniProt: O75794)

PDB	External Database	Details
Mse -19	-	initiating methionine
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

B, D: 362 - 472 (UniProt: P41091)

PDB	External Database	Details
Mse 361	-	initiating methionine

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	107866.0
Non-Polymers*	Number of molecules	2
	Total formula weight	1014.4
All*	Total formula weight	108880.4

*Water molecules are not included.