8PHI
Crystal structure of prefusion-stabilized RSV F Variant DS-Cav1 in complex with Lonafarnib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | F | Fusion glycoprotein F0 | polymer | 557 | 61581.1 | 1 | UniProt (W8RJF9) Pfam (PF00523) UniProt (by SIFTS) (P03420) In PDB | Human respiratory syncytial virus A2 | |
| 2 | F | 4-{2-[4-(3,10-DIBROMO-8-CHLORO-6,11-DIHYDRO-5H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YL)PIPERIDIN-1-YL]-2-OXOETHYL}PIPERIDINE-1-CARBOXAMIDE | non-polymer | 638.8 | 1 | Chemie (336) | |||
| 3 | F | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | F | 2-(2-METHOXYETHOXY)ETHANOL | non-polymer | 120.1 | 2 | Chemie (PG0) | |||
| 5 | F | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 6 | water | water | 18.0 | 177 | Chemie (HOH) |
Sequence modifications
F: 26 - 513 (UniProt: W8RJF9)
| PDB | External Database | Details |
|---|---|---|
| Glu 66 | Lys 66 | conflict |
| Cys 155 | Ser 155 | conflict |
| Phe 190 | Ser 190 | conflict |
| Leu 207 | Val 207 | conflict |
| Cys 290 | Ser 290 | conflict |
| Ser 514 | - | expression tag |
| Ala 515 | - | expression tag |
| Ile 516 | - | expression tag |
| Gly 517 | - | expression tag |
| Gly 518 | - | expression tag |
| Tyr 519 | - | expression tag |
| Ile 520 | - | expression tag |
| Pro 521 | - | expression tag |
| Glu 522 | - | expression tag |
| Ala 523 | - | expression tag |
| Pro 524 | - | expression tag |
| Arg 525 | - | expression tag |
| Asp 526 | - | expression tag |
| Gly 527 | - | expression tag |
| Gln 528 | - | expression tag |
| Ala 529 | - | expression tag |
| Tyr 530 | - | expression tag |
| Val 531 | - | expression tag |
| Arg 532 | - | expression tag |
| Lys 533 | - | expression tag |
| Asp 534 | - | expression tag |
| Gly 535 | - | expression tag |
| Glu 536 | - | expression tag |
| Trp 537 | - | expression tag |
| Val 538 | - | expression tag |
| Leu 539 | - | expression tag |
| Leu 540 | - | expression tag |
| Ser 541 | - | expression tag |
| Thr 542 | - | expression tag |
| Phe 543 | - | expression tag |
| Leu 544 | - | expression tag |
| Gly 545 | - | expression tag |
| Gly 546 | - | expression tag |
| Leu 547 | - | expression tag |
| Val 548 | - | expression tag |
| Pro 549 | - | expression tag |
| Arg 550 | - | expression tag |
| Gly 551 | - | expression tag |
| Ser 552 | - | expression tag |
| Ser 553 | - | expression tag |
| Ala 554 | - | expression tag |
| Trp 555 | - | expression tag |
| Ser 556 | - | expression tag |
| His 557 | - | expression tag |
| Pro 558 | - | expression tag |
| Gln 559 | - | expression tag |
| Phe 560 | - | expression tag |
| Glu 561 | - | expression tag |
| Lys 562 | - | expression tag |
| Gly 563 | - | expression tag |
| Gly 564 | - | expression tag |
| Gly 565 | - | expression tag |
| Ser 566 | - | expression tag |
| Gly 567 | - | expression tag |
| Gly 568 | - | expression tag |
| Gly 569 | - | expression tag |
| Ser 570 | - | expression tag |
| Gly 571 | - | expression tag |
| Gly 572 | - | expression tag |
| Gly 573 | - | expression tag |
| Ser 574 | - | expression tag |
| Trp 575 | - | expression tag |
| Ser 576 | - | expression tag |
| His 577 | - | expression tag |
| Pro 578 | - | expression tag |
| Gln 579 | - | expression tag |
| Phe 580 | - | expression tag |
| Glu 581 | - | expression tag |
| Lys 582 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 61581.1 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1015.3 | |
| All* | Total formula weight | 62596.4 |
