8PAW
Crystal structure of MST1 with a MAP4K1 SMOL inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Serine/threonine-protein kinase 4 37kDa subunit | polymer | 312 | 35595.7 | 2 | UniProt (Q13043) Pfam (PF00069) | Homo sapiens (human) | MST1/N |
| 2 | C (A) | ASPARTIC ACID | non-polymer | 133.1 | 1 | Chemie (ASP) | |||
| 3 | D, G (A, B) | 1-[3,5-bis(fluoranyl)-4-[[3-(1-propan-2-ylpyrazol-3-yl)-1~{H}-pyrrolo[2,3-b]pyridin-4-yl]oxy]phenyl]-3-(2-methoxyethyl)urea | non-polymer | 470.5 | 2 | Chemie (XQL) | |||
| 4 | E, H (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | F, I (A, B) | 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID | non-polymer | 221.3 | 2 | Chemie (CXS) | |||
| 6 | J, K (A, B) | water | water | 18.0 | 305 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 311 (UniProt: Q13043)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 71191.4 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1700.9 | |
| All* | Total formula weight | 72892.3 |
