8P9C
Crystal structure of p63-p73 heterotetramer (tetramerisation domain) in complex with darpin 1810 F11
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tumor protein 63 | polymer | 61 | 7380.2 | 1 | UniProt (Q9H3D4) Pfam (PF07710) | Homo sapiens (human) | p63,Chronic ulcerative stomatitis protein,CUSP,Keratinocyte transcription factor KET,Transformation-related protein 63,TP63,Tumor protein p73-like,p73L,p40,p51 |
| 2 | B (B) | Tumor protein p73 | polymer | 50 | 6034.9 | 1 | UniProt (O15350) Pfam (PF07710) | Homo sapiens (human) | p53-like transcription factor,p53-related protein |
| 3 | C (C) | Darpin 1810 F11 | polymer | 159 | 16873.0 | 1 | Lama glama (Llama) | ||
| 4 | D, E, F, G (C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 5 | H, I, J (A, B, C) | water | water | 18.0 | 164 | Chemie (HOH) |
Sequence modifications
A: 358 - 416 (UniProt: Q9H3D4)
B: 351 - 398 (UniProt: O15350)
| PDB | External Database | Details |
|---|---|---|
| Gly 356 | - | expression tag |
| Ser 357 | - | expression tag |
| Glu 377 | Lys 416 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 349 | - | expression tag |
| Ser 350 | - | expression tag |
| Lys 363 | Glu 363 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 30288.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 248.3 | |
| All* | Total formula weight | 30536.4 |
