8P5J
Kinase domain of mutant human ULK1 in complex with compound WZ4003
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Serine/threonine-protein kinase ULK1 | polymer | 284 | 32121.1 | 2 | UniProt (O75385) Pfam (PF00069) | Homo sapiens (human) | Autophagy-related protein 1 homolog,ATG1,hATG1,Unc-51-like kinase 1 |
| 2 | C, E (A, B) | ~{N}-[3-[5-chloranyl-2-[[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]oxyphenyl]propanamide | non-polymer | 497.0 | 2 | Chemie (WYT) | |||
| 3 | D, F (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | G (B) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 5 | H, I (A, B) | water | water | 18.0 | 272 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 283 (UniProt: O75385)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
| Ala 245 | Arg 245 | engineered mutation |
| Ala 246 | Glu 246 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 64242.2 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1065.6 | |
| All* | Total formula weight | 65307.8 |
