8P0A
Human Cohesin ATPase module
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Structural maintenance of chromosomes protein 1A | polymer | 456 | 51443.2 | 1 | UniProt (Q14683) Pfam (PF02463) | Homo sapiens (human) | SMC protein 1A,SMC-1-alpha,SMC-1A,Sb1.8 |
| 2 | B (B) | Structural maintenance of chromosomes protein 3 | polymer | 462 | 52391.4 | 1 | UniProt (Q9UQE7) Pfam (PF02463) | Homo sapiens (human) | SMC protein 3,SMC-3,Basement membrane-associated chondroitin proteoglycan,Bamacan,Chondroitin sulfate proteoglycan 6,Chromosome-associated polypeptide,hCAP |
| 3 | C (C) | 64-kDa C-terminal product | polymer | 81 | 9203.6 | 1 | UniProt (O60216) Pfam (PF04824) | Homo sapiens (human) | 64-kDa carboxy-terminal product,65-kDa carboxy-terminal product |
| 4 | D, F (A, B) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 5 | E, G (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) |
Sequence modifications
A: 1 - 977 (UniProt: Q14683)
A: 992 - 1233 (UniProt: Q14683)
B: 1 - 966 (UniProt: Q9UQE7)
B: 979 - 1217 (UniProt: Q9UQE7)
C: 558 - 629 (UniProt: O60216)
A: 992 - 1233 (UniProt: Q14683)
| PDB | External Database | Details |
|---|---|---|
| Glu 978 | - | linker |
| Ser 979 | - | linker |
| Ser 980 | - | linker |
| Lys 981 | - | linker |
| His 982 | - | linker |
| Pro 983 | - | linker |
| Thr 984 | - | linker |
| Ser 985 | - | linker |
| Leu 986 | - | linker |
| Val 987 | - | linker |
| Pro 988 | - | linker |
| Arg 989 | - | linker |
| Gly 990 | - | linker |
| Ser 991 | - | linker |
| Gln 1157 | Glu 1157 | engineered mutation |
B: 979 - 1217 (UniProt: Q9UQE7)
| PDB | External Database | Details |
|---|---|---|
| Gly 967 | - | linker |
| Ser 968 | - | linker |
| Gly 969 | - | linker |
| Ser 970 | - | linker |
| Leu 971 | - | linker |
| Val 972 | - | linker |
| Pro 973 | - | linker |
| Arg 974 | - | linker |
| Gly 975 | - | linker |
| Ser 976 | - | linker |
| Gly 977 | - | linker |
| Ser 978 | - | linker |
| Gln 1144 | Glu 1144 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met 557 | - | initiating methionine |
| Gly 630 | - | expression tag |
| Ser 631 | - | expression tag |
| Leu 632 | - | expression tag |
| Glu 633 | - | expression tag |
| Val 634 | - | expression tag |
| Leu 635 | - | expression tag |
| Phe 636 | - | expression tag |
| Gln 637 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 113038.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1063.0 | |
| All* | Total formula weight | 114101.2 |
