8P08
Crystal structure of human CLK1 in complex with Leucettinib-21
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Dual specificity protein kinase CLK1 | polymer | 339 | 39581.5 | 1 | UniProt (P49759) Pfam (PF00069) In PDB | Homo sapiens (human) | CDC-like kinase 1 |
| 2 | A | (4~{Z})-4-(1,3-benzothiazol-6-ylmethylidene)-2-[[(2~{R})-1-methoxy-4-methyl-pentan-2-yl]amino]-1~{H}-imidazol-5-one | non-polymer | 358.5 | 1 | Chemie (WAZ) | |||
| 3 | water | water | 18.0 | 53 | Chemie (HOH) |
Sequence modifications
A: 148 - 484 (UniProt: P49759)
| PDB | External Database | Details |
|---|---|---|
| Ser 146 | - | expression tag |
| Met 147 | - | expression tag |
| Ala 432 | Arg 432 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 39581.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 358.5 | |
| All* | Total formula weight | 39940.0 |
