8OXS
Cholera holotoxin variant (chimera with E. coli heat-labile enterotoxin, 4 C-terminal substitutions)
This is a non-PDB format compatible entry.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Cholera enterotoxin subunit A | polymer | 240 | 27266.1 | 2 | UniProt (P01555) Pfam (PF01375) In PDB | Vibrio cholerae O1 | Cholera enterotoxin,A chain |
2 | D, E, F, G, H... | Cholera enterotoxin subunit B | polymer | 103 | 11623.3 | 10 | UniProt (P01556) Pfam (PF01376) In PDB | Vibrio cholerae O1 | Cholera enterotoxin B chain,Cholera enterotoxin gamma chain,Choleragenoid |
3 | A, B | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
4 | C, I, K, L, A... | beta-D-galactopyranose | non-polymer | 180.2 | 10 | Chemie (GAL) | |||
5 | C, K, L, D, E... | alpha-D-galactopyranose | non-polymer | 180.2 | 7 | Chemie (GLA) | |||
6 | B, I, E, H | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 4 | Chemie (EPE) | |||
7 | water | water | 18.0 | 764 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 240 (UniProt: P01555)
D, E, F, G, H, C, I, J, K, L: 1 - 103 (UniProt: P01556)
PDB | External Database | Details |
---|---|---|
Glu 229 | Asp 247 | engineered mutation |
Val 230 | Ile 248 | engineered mutation |
Ile 232 | Thr 250 | engineered mutation |
Tyr 233 | His 251 | engineered mutation |
PDB | External Database | Details |
---|---|---|
His 18 | Tyr 39 | engineered mutation |
Thr 47 | Ile 68 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 12 |
Total formula weight | 170764.8 | |
Non-Polymers* | Number of molecules | 23 |
Total formula weight | 4061.9 | |
All* | Total formula weight | 174826.6 |