8OXS

Cholera holotoxin variant (chimera with E. coli heat-labile enterotoxin, 4 C-terminal substitutions)

This is a non-PDB format compatible entry.

Functional Information from PROSITE/UniProt

site_id	PS00014
Number of Residues	4
Details	ER_TARGET Endoplasmic reticulum targeting sequence. KDEL

Chain	Residue	Details
A	LYS237-LEU240

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000250

Chain	Residue	Details
A	GLU112
B	GLU112

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:16099990

Chain	Residue	Details
A	ARG7
A	MET23
B	ARG7
B	MET23

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	4
Details	M-CSA 919

Chain	Residue	Details
A	ARG7	electrostatic stabiliser
A	SER61	electrostatic stabiliser
A	GLU110	proton shuttle (general acid/base)
A	GLU112	electrostatic stabiliser

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site_id	MCSA2
Number of Residues	4
Details	M-CSA 919

Chain	Residue	Details
B	ARG7	electrostatic stabiliser
B	SER61	electrostatic stabiliser
B	GLU110	proton shuttle (general acid/base)
B	GLU112	electrostatic stabiliser

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