8OXS

Cholera holotoxin variant (chimera with E. coli heat-labile enterotoxin, 4 C-terminal substitutions)

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005534	molecular_function	galactose binding
A	0005615	cellular_component	extracellular space
A	0008289	molecular_function	lipid binding
A	0016740	molecular_function	transferase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
A	0042597	cellular_component	periplasmic space
A	0090729	molecular_function	toxin activity
A	0141104	biological_process	symbiont-mediated activation of host G protein-coupled receptor signal transduction
A	1902494	cellular_component	catalytic complex
B	0005515	molecular_function	protein binding
B	0005534	molecular_function	galactose binding
B	0005615	cellular_component	extracellular space
B	0008289	molecular_function	lipid binding
B	0016740	molecular_function	transferase activity
B	0016757	molecular_function	glycosyltransferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
B	0042597	cellular_component	periplasmic space
B	0090729	molecular_function	toxin activity
B	0141104	biological_process	symbiont-mediated activation of host G protein-coupled receptor signal transduction
B	1902494	cellular_component	catalytic complex
C	0005515	molecular_function	protein binding
C	0005534	molecular_function	galactose binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0020002	cellular_component	host cell plasma membrane
C	0035821	biological_process	modulation of process of another organism
C	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
C	0042597	cellular_component	periplasmic space
C	0046812	molecular_function	host cell surface binding
C	0090729	molecular_function	toxin activity
C	1902494	cellular_component	catalytic complex
D	0005515	molecular_function	protein binding
D	0005534	molecular_function	galactose binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0020002	cellular_component	host cell plasma membrane
D	0035821	biological_process	modulation of process of another organism
D	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
D	0042597	cellular_component	periplasmic space
D	0046812	molecular_function	host cell surface binding
D	0090729	molecular_function	toxin activity
D	1902494	cellular_component	catalytic complex
E	0005515	molecular_function	protein binding
E	0005534	molecular_function	galactose binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0020002	cellular_component	host cell plasma membrane
E	0035821	biological_process	modulation of process of another organism
E	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
E	0042597	cellular_component	periplasmic space
E	0046812	molecular_function	host cell surface binding
E	0090729	molecular_function	toxin activity
E	1902494	cellular_component	catalytic complex
F	0005515	molecular_function	protein binding
F	0005534	molecular_function	galactose binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0020002	cellular_component	host cell plasma membrane
F	0035821	biological_process	modulation of process of another organism
F	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
F	0042597	cellular_component	periplasmic space
F	0046812	molecular_function	host cell surface binding
F	0090729	molecular_function	toxin activity
F	1902494	cellular_component	catalytic complex
G	0005515	molecular_function	protein binding
G	0005534	molecular_function	galactose binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0020002	cellular_component	host cell plasma membrane
G	0035821	biological_process	modulation of process of another organism
G	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
G	0042597	cellular_component	periplasmic space
G	0046812	molecular_function	host cell surface binding
G	0090729	molecular_function	toxin activity
G	1902494	cellular_component	catalytic complex
H	0005515	molecular_function	protein binding
H	0005534	molecular_function	galactose binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0020002	cellular_component	host cell plasma membrane
H	0035821	biological_process	modulation of process of another organism
H	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
H	0042597	cellular_component	periplasmic space
H	0046812	molecular_function	host cell surface binding
H	0090729	molecular_function	toxin activity
H	1902494	cellular_component	catalytic complex
I	0005515	molecular_function	protein binding
I	0005534	molecular_function	galactose binding
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	0020002	cellular_component	host cell plasma membrane
I	0035821	biological_process	modulation of process of another organism
I	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
I	0042597	cellular_component	periplasmic space
I	0046812	molecular_function	host cell surface binding
I	0090729	molecular_function	toxin activity
I	1902494	cellular_component	catalytic complex
J	0005515	molecular_function	protein binding
J	0005534	molecular_function	galactose binding
J	0005576	cellular_component	extracellular region
J	0005615	cellular_component	extracellular space
J	0020002	cellular_component	host cell plasma membrane
J	0035821	biological_process	modulation of process of another organism
J	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
J	0042597	cellular_component	periplasmic space
J	0046812	molecular_function	host cell surface binding
J	0090729	molecular_function	toxin activity
J	1902494	cellular_component	catalytic complex
K	0005515	molecular_function	protein binding
K	0005534	molecular_function	galactose binding
K	0005576	cellular_component	extracellular region
K	0005615	cellular_component	extracellular space
K	0020002	cellular_component	host cell plasma membrane
K	0035821	biological_process	modulation of process of another organism
K	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
K	0042597	cellular_component	periplasmic space
K	0046812	molecular_function	host cell surface binding
K	0090729	molecular_function	toxin activity
K	1902494	cellular_component	catalytic complex
L	0005515	molecular_function	protein binding
L	0005534	molecular_function	galactose binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0020002	cellular_component	host cell plasma membrane
L	0035821	biological_process	modulation of process of another organism
L	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
L	0042597	cellular_component	periplasmic space
L	0046812	molecular_function	host cell surface binding
L	0090729	molecular_function	toxin activity
L	1902494	cellular_component	catalytic complex

Functional Information from PROSITE/UniProt

site_id	PS00014
Number of Residues	4
Details	ER_TARGET Endoplasmic reticulum targeting sequence. KDEL

Chain	Residue	Details
A	LYS237-LEU240

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16099990","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	4
Details	M-CSA 919

Chain	Residue	Details
A	ARG7	electrostatic stabiliser
A	SER61	electrostatic stabiliser
A	GLU110	proton shuttle (general acid/base)
A	GLU112	electrostatic stabiliser

---

site_id	MCSA2
Number of Residues	4
Details	M-CSA 919

Chain	Residue	Details
G	ASP7	electrostatic stabiliser
G	GLN61	electrostatic stabiliser

---