8OUU
Crystal structure of D1228V c-MET bound by compound 29
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Hepatocyte growth factor receptor | polymer | 309 | 34826.4 | 2 | UniProt (P08581) Pfam (PF07714) | Homo sapiens (human) | HGF receptor,HGF/SF receptor,Proto-oncogene c-Met,Scatter factor receptor,SF receptor,Tyrosine-protein kinase Met |
| 2 | C (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 3 | D, G, H (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 4 | E, I, J (A, B) | FORMIC ACID | non-polymer | 46.0 | 3 | Chemie (FMT) | |||
| 5 | F, K (A, B) | 5-(3-ethynyl-5-fluoranyl-1H-indazol-7-yl)-1-[(1S)-1-phenylethyl]pyrimidine-2,4-dione | non-polymer | 374.4 | 2 | Chemie (W49) | |||
| 6 | L, M (A, B) | water | water | 18.0 | 431 | Chemie (HOH) |
Sequence modifications
A, B: 1038 - 1346 (UniProt: P08581)
| PDB | External Database | Details |
|---|---|---|
| Val 1228 | Asp 1228 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 69652.7 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1165.1 | |
| All* | Total formula weight | 70817.8 |
